Hyperglycemia and Acute Pancreatitis

NCT06590233 | Completed

• 1 other identifier: NMU-3cDM-1A
• Study Type: observational
• Target: 4,500
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (PPDM-A). The main questions it aims to answer are:

1. 1.What are the clinical characteristics of PPDM-A?
2. 2.What are the related factors for PPDM-A?

Conditions

Acute Pancreatitis (AP); Diabetes Mellitus

Keywords

Acute pancreatitis; Diabetes mellitus; PPDM-A; Risk factor

Outcome Measures

Primary Outcomes (1)

• Number of participants who have developed PPDM-A

  PPDM-A was defined as diabetes after AP in the absence of a history of preexisting diabetes before the AP episode.

  From the AP treatment to 5 years after the end of treatment

Study Arms (1)

Acute pancreatitis

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We collected data from patients with acute pancreatitis (AP) in participating centers between January 2013 and June 2024.

You may qualify if:

• Patients with pancreatitis attending participating centers since January 2013 (patients with clinically reported AP (ICD-10:K85 or related diagnosis));
• Age between 18 and 80 years;
• Patients have undergone glucose metabolic tests at least 1 month after discharge from hospital.

You may not qualify if:

• Patients with a history of diabetes mellitus prior to the AP attack;
• Patients who underwent pancreatic surgery;
• Patients with hereditary pancreatitis and autoimmune pancreatitis;
• Patients with missing data regarding age or gender.

Sponsors & Collaborators

• Shanghai Changzheng Hospital: lead
• Changhai Hospital: collaborator

Related Publications (8)

• Bharmal SH, Cho J, Ko J, Petrov MS. Glucose variability during the early course of acute pancreatitis predicts two-year probability of new-onset diabetes: A prospective longitudinal cohort study. United European Gastroenterol J. 2022 Mar;10(2):179-189. doi: 10.1002/ueg2.12190. Epub 2022 Feb 20.

  PMID: 35188346 BACKGROUND

• Bharmal SH, Cho J, Alarcon Ramos GC, Ko J, Stuart CE, Modesto AE, Singh RG, Petrov MS. Trajectories of glycaemia following acute pancreatitis: a prospective longitudinal cohort study with 24 months follow-up. J Gastroenterol. 2020 Aug;55(8):775-788. doi: 10.1007/s00535-020-01682-y. Epub 2020 Jun 3.

  PMID: 32494905 BACKGROUND

• Zhong S, Du Q, Liu N, Chen Y, Yang T, Qin S, Jiang Y, Huang X. Developing a CT-based radiomics nomogram for predicting post-acute pancreatitis diabetes mellitus incidence. Br J Radiol. 2023 Dec;96(1152):20230382. doi: 10.1259/bjr.20230382. Epub 2023 Oct 24.

  PMID: 37750855 BACKGROUND

• Lv Y, Zhang J, Yang T, Sun J, Hou J, Chen Z, Yu X, Yuan X, Lu X, Xie T, Yu T, Su X, Liu G, Zhang C, Li L. Non-Alcoholic Fatty Liver Disease (NAFLD) Is an Independent Risk Factor for Developing New-Onset Diabetes After Acute Pancreatitis: A Multicenter Retrospective Cohort Study in Chinese Population. Front Endocrinol (Lausanne). 2022 May 25;13:903731. doi: 10.3389/fendo.2022.903731. eCollection 2022.

  PMID: 35692404 BACKGROUND

• Yu BJ, Li NS, He WH, He C, Wan JH, Zhu Y, Lu NH. Pancreatic necrosis and severity are independent risk factors for pancreatic endocrine insufficiency after acute pancreatitis: A long-term follow-up study. World J Gastroenterol. 2020 Jun 21;26(23):3260-3270. doi: 10.3748/wjg.v26.i23.3260.

  PMID: 32684740 BACKGROUND

• Zhi M, Zhu X, Lugea A, Waldron RT, Pandol SJ, Li L. Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic Review and Meta-Analysis. Front Physiol. 2019 May 31;10:637. doi: 10.3389/fphys.2019.00637. eCollection 2019.

  PMID: 31231233 BACKGROUND

• Das SL, Singh PP, Phillips AR, Murphy R, Windsor JA, Petrov MS. Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis. Gut. 2014 May;63(5):818-31. doi: 10.1136/gutjnl-2013-305062. Epub 2013 Aug 8.

  PMID: 23929695 BACKGROUND

• Shen HN, Yang CC, Chang YH, Lu CL, Li CY. Risk of Diabetes Mellitus after First-Attack Acute Pancreatitis: A National Population-Based Study. Am J Gastroenterol. 2015 Dec;110(12):1698-706. doi: 10.1038/ajg.2015.356. Epub 2015 Nov 3.

  PMID: 26526084 BACKGROUND

MeSH Terms

Conditions

Pancreatitis; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Director

Study Record Dates

• First Submitted: August 29, 2024
• First Posted: September 19, 2024
• Study Start: January 1, 2013
• Primary Completion: August 1, 2024
• Study Completion: August 1, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share