Comparison of Serum SIRT-1 and MMP-9 Levels of Patients With Bronchiectasis and Healthy Controls

NCT06589492 | Completed DMC

• 1 other identifier: Biochemistry AD
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this a cross-sectinol study is to measure the levels of MMP-9 and SIRT-1 levels in patients with bronchiectasis and healthy controls. The aim is to compare the serum levels of these molecules between patients and controls.

• Is the MMP-9 level increasing or decreasing?
• Is the SIRT-1 level increasing or decreasing in patients?
• Is the disease related to age and gender? Participants will only have one 5 ml blood sample drawn when they visit the chest illness clinic. Molecule levels will be measured in this blood's serum. The patient group participants will be scanned once with high-resolution chest CT. Apart from this, comparisons will be made using the age and gender information of the participants.

Conditions

Bronchiectasis Adult

Keywords

Bronchiectasis; MMP-9; SIRT-1

Outcome Measures

Primary Outcomes (1)

• MMP-9 and SIRT-1 levels (ng/mL) mesurment in the blood serum to compare between patient and control.

  MMP-9 and SIRT-1 levels mesured in the blood serum. The most common side effect when blood is taken from the patient is slight bruising and swelling in the arm due to needle sticking. There will be no other serious side effects.

  not measured in time frame. general (1. day)

Study Arms (3)

CT scan

NO INTERVENTION

Chest high-resolution CT scan will be performed for diagnosis of patients.

Age, gender

NO INTERVENTION

Age and gender information of patients will be obtained for comparison.

Measurement of MMP-9 and SIRT-1 levels in blood serum

EXPERIMENTAL

It involves taking 5ml of blood from participants to measure mmp-9 and SIRT-1 levels in blood serum.

Diagnostic Test: Measurement of MMP-9 and SIRT-1 levels in blood serum

Interventions

Measurement of MMP-9 and SIRT-1 levels in blood serum DIAGNOSTIC_TEST

Measurement of MMP-9 and SIRT-1 levels in blood serum, Collection of 5 ml Blood samples

Measurement of MMP-9 and SIRT-1 levels in blood serum

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Bronchiectasis patients who were symptoms (cough, sputum production)
• Individuals whose diagnosis was confirmed by a high-resolution chest CT scan taken within the previous year

You may not qualify if:

• Individuals with bronchiectasis associated with cystic fibrosis and who had a worsening episode
• individuals who were pregnant or nursing
• those with low comprehension
• taken antibiotics during the previous four weeks

Sponsors & Collaborators

• Cumhuriyet University: lead

Study Sites (1)

Cumhuriyet University

Sivas, Si̇vas Centre, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Bronchiectasis

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: September 4, 2024
• First Posted: September 19, 2024
• Study Start: November 2, 2020
• Primary Completion: September 2, 2022
• Study Completion: September 2, 2022
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)