Children With High Genetic Susceptibility Benefit More From Short-term Physical Activity Interventions

NCT06583421 | Completed

• 1 other identifier: Ethics Approval No. [2020] 075
• Study Type: interventional
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

Sharp increase in childhood obesity has been regarded as one of the most serious but preventable global public health challenges. Engaging children in moderate-to-vigorous physical activity (MVPA) is important to address the obesity problem as it is associated with a host of obesity outcomes including body weight, BMI, body fat percentage, waist circumference, lean body mass, systolic blood pressure, insulin sensitivity, cardiovascular health, and cognitive development. In China, only about one-third of children meet the recommended guidelines of at least 60 minutes of MVPA per day, and obesity rates are rising. Children with different generic characteristics may benefit differently from MVPA, which should not be neglected when conducting interventions among children. However, most of the evidence about how genes interact with MVPA on obesity among children were addressed from cross-sectional design or synthetic lifestyle interventions. Change-on-change analysis was used in our study based on a randomized controlled trial of MVPA intervention to discusses the effect of genetics and physical activity on obesity indicators. In addition, investigators used Generic risk scores (GRSs) based on 14 BMI-associated SNPs to assess generic variation of Chinese children.

Conditions

Physical Inactivity; Obesity, Childhood

Keywords

Obesity; Physical activity; Genetic susceptibility; Interaction

Outcome Measures

Primary Outcomes (8)

• Physical activity strength

  Strength was measured by Tri-axial body motion recorder (ActiGraph, Wgt3x-BT, USA) to maintain relative intensity. Children were required to wear ActiGraph by a professional investigator on the left wrist, loosely tightened, and required to wear it at all times except for the shower during the intervention for 7 days.

  During the 4-week intervention

• Height

  eight was measured to the nearest 0.1cm using Height Measuring Ruler (Selcom, Germany).

  At baseline and after 4-week of intervention

• Body weight

  Body weight was measured to the nearest 0.1kg using Body Composition Analyzer (DC-13, Parade, Japan)

  At baseline and after 4-week of intervention

• Fat mass

  Fat mass was measured to the nearest 0.1kg using Body Composition Analyzer (DC-13, Parade, Japan).

  At baseline and after 4-week of intervention

• Waist circumference

  Waist circumference was measured to the nearest 0.1cm with measuring tape.

  At baseline and after 4-week of intervention

• Hip circumference

  Hip circumference was measured to the nearest 0.1cm with measuring tape.

  At baseline and after 4-week of intervention

• Preperitoneal fat

  Preperitoneal fat was measured by ultrasonography. The thickness and area of preperitoneal fat was measured with a linear array probe L12-5 (38 mm, 5-12 HZ) according to the method of Suzuki.

  At baseline and after 4-week of intervention

• Abdominal subcutaneous fat thickness

  Abdominal subcutaneous fat thickness was measured by ultrasonography. The thickness and area of abdominal subcutaneous fat was measured with a linear array probe L12-5 (38 mm, 5-12 HZ) according to the method of Suzuki.

  At baseline and after 4-week of intervention

Study Arms (2)

4-week MVPA intervention group

EXPERIMENTAL

The 4-week MVPA intervention engaged in supervised aerobic exercise, resistance training and interesting sport for 60 minutes, 3 days/week (Monday, Wednesday and Friday). As shown in Table S1, participants completed four sessions including preparation module (15 min), training module (30 min), and relaxation module (15 min). Another aerobic module (15 min) was added in each Friday. Children in intervention group were also encouraged to take exercise for 10 minutes together with their parents at home two hours later after dinner including ten minutes' walking (at least 1000 meters) or at least 200 times rope skipping.

Behavioral: 4-week MVPA intervention

Control group

NO INTERVENTION

No physical activity interventions were conducted in the control group. In order to safeguard the rights of the control groups, the same physical activity intervention was given to the control group at the end of the research.

Interventions

4-week MVPA intervention BEHAVIORAL

The 4-week MVPA intervention engaged in supervised aerobic exercise, resistance training and interesting sport for 60 minutes, 3 days/week (Monday, Wednesday and Friday). As shown in Table S1, participants completed four sessions including preparation module (15 min), training module (30 min), and relaxation module (15 min). Another aerobic module (15 min) was added in each Friday.

4-week MVPA intervention group

Eligibility Criteria

• Age: 10 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• obese children aged 10-12 years

You may not qualify if:

• obesity due to disease
• persons with limited physical activity

Sponsors & Collaborators

• China Medical University, China: lead

Study Sites (1)

China Medical University

Shenyang, China

Location

MeSH Terms

Conditions

Sedentary Behavior; Pediatric Obesity; Obesity; Motor Activity; Genetic Predisposition to Disease

Condition Hierarchy (Ancestors)

Behavior; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Disease Susceptibility; Disease Attributes; Pathologic Processes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master student

Study Record Dates

• First Submitted: August 22, 2024
• First Posted: September 4, 2024
• Study Start: April 1, 2022
• Primary Completion: August 1, 2022
• Study Completion: August 1, 2022
• Last Updated: September 4, 2024

Record last verified: 2024-08

Locations

CN (1)