NCT06577181

Brief Summary

Intramuscular injection of HCG to prepare endometrium for frozen embryo transfer

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
0mo left

Started May 2024

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 10, 2024

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

August 27, 2024

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 29, 2024

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 10, 2025

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

May 10, 2026

Expected
Last Updated

September 19, 2024

Status Verified

September 1, 2024

Enrollment Period

1 year

First QC Date

August 27, 2024

Last Update Submit

September 6, 2024

Conditions

IVF

Outcome Measures

Primary Outcomes (1)

  • Clinical pregnancy

    Presence of at least one gestational sac inside the uterus 28 days after embryo transfer

    2months

Study Arms (2)

Women undergoing preparation for Embryo transfer

Group who received intramuscular injection of HCG before embryo transfer

Drug: hCG + estradiol

Women undergoing preparation for Embryo transfer 1

Group who did not receive intramuscular injection of HCG before embryo transfer

Other: Observation arm

Interventions

hCG + estradiolDRUG

Human chorionic gonadotropins

Women undergoing preparation for Embryo transfer
Observation armOTHER

estradiol only wuithout giving hcg

Women undergoing preparation for Embryo transfer 1

Eligibility Criteria

Sexfemale(Gender-based eligibility)
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Reproductive age female

You may qualify if:

  • Infertile women being prepared for frozen embryo transfer (FET) in an ART program

You may not qualify if:

  • (1) Use of preimplantation genetic test.
  • History of recurrent spontaneous abortion.
  • Presence of congenital uterine malformations.
  • Use of sequential embryo transfer.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assiut university

Asyut, Asyut Governorate, 77777, Egypt

Location

Related Publications (1)

  • Eftekhar M, Rahmani E, Eftekhar T. Effect of adding human chorionic gonadotropin to the endometrial preparation protocol in frozen embryo transfer cycles. Int J Fertil Steril. 2012 Oct;6(3):175-8. Epub 2012 Dec 17.

    PMID: 24520435BACKGROUND

MeSH Terms

Interventions

Estradiol

Intervention Hierarchy (Ancestors)

EstrenesEstranesSteroidsFused-Ring CompoundsPolycyclic CompoundsEstradiol CongenersGonadal Steroid HormonesGonadal HormonesHormonesHormones, Hormone Substitutes, and Hormone Antagonists

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof. Ahmed nabil

Study Record Dates

First Submitted

August 27, 2024

First Posted

August 29, 2024

Study Start

May 10, 2024

Primary Completion

May 10, 2025

Study Completion (Estimated)

May 10, 2026

Last Updated

September 19, 2024

Record last verified: 2024-09

Locations

EG(1)