High-intensity Interval Circuit Training in People With Parkinson Disease

NCT06576817 | Completed

• 1 other identifier: 24-003
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of the study is to compare different types of high intensity circuit exercises over an 8-class training series in people with Parkinson disease. The main question it aims to answer is:

• Does including arm and hand exercises with leg exercises improve reaction time, balance, functional measures, gait speed and quality of life? This group will be compared to a group that only does leg exercises. Participants will be asked to participate in 8 high intensity circuit exercise classes.

Conditions

Parkinson Disease

Keywords

exercise

Outcome Measures

Primary Outcomes (7)

• Trail making Test Parts A and B (timed, higher scores mean worse outcome)

  Cognitive and fine motor skills

  8-10 weeks

• Activity-specific Balance Confidence Scale (0-100%, higher scores mean better outcome)

  Balance confidence self-report

  8-10 weeks

• Timed Up and Go

  Balance and function

  8-10 weeks

• 10 meter Walk Test

  Gait Speed

  8-10 weeks

• 6 minute walk test

  endurance

  8-10 weeks

• 9-hole peg test (timed, higher scores mean worse outcome)

  fine motor

  8-10 weeks

• Parkinson's Disease Questionnaire - Short Form (8) (Score 0-32, higher scores mean worse outcome)

  Quality of Life

  8-10 weeks

Study Arms (2)

Lower extremity and upper extremity exercise

EXPERIMENTAL

Exercises in the circuit (8 total) will focus on the lower extremity (4) and upper extremity (4)

Other: High intensity circuit exercise class - Lower and upper extremity

Lower extremity exercise

ACTIVE COMPARATOR

Exercises in the circuit (8 total) will focus on the lower extremity (4) alone.

Other: High intensity circuit exercise class - Lower extremity alone

Interventions

High intensity circuit exercise class - Lower and upper extremity OTHER

Exercises performed at high intensity effort in the circuit (8 total) will focus on both the lower extremity (4) and upper extremity (4)

Lower extremity and upper extremity exercise

High intensity circuit exercise class - Lower extremity alone OTHER

All exercises performed at high intensity effort in the circuit (8 total) will focus on the lower extremity alone

Lower extremity exercise

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of Parkinson's disease
• Hoehn and Yahr level of 1 to 3
• ability to walk independently with or without an assistive device
• obtain medical clearance to participate in moderate or vigorous exercise.

You may not qualify if:

• diagnosis of any neurological disease other than PD (including but not limited to stroke, dementia, and multiple sclerosis; mild cognitive impairment is not excluded)
• bone instability (non-consolidated fractures, unstable spinal column, severe osteoporosis)
• muscle or ligament tears
• uncontrolled hypertension
• uncontrolled diabetes
• severe cardiovascular disease that impairs walking or exercise
• a major change in medication during the study training period (pre-test to post-test)

Sponsors & Collaborators

• Pacific Northwest University of Health Sciences: lead

Study Sites (1)

Pacific Northwest University of Health Sciences

Yakima, Washington, 98901, United States

Location

MeSH Terms

Conditions

Parkinson Disease; Motor Activity

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Behavior

Study Officials

• Tiffany B Salido, DPT, PhD

  Pacific Northwest University of Health Sciences

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Participants will be told exercise stations may vary within-session and week to week but will not be informed that only one group has UE exercise interventions. Assessors are blinded to group allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Single center, two arm, pre-test post-test parallel design with up to 4 cohorts of class participants.

Study Record Dates

• First Submitted: July 12, 2024
• First Posted: August 29, 2024
• Study Start: February 15, 2024
• Primary Completion: November 30, 2025
• Study Completion: November 30, 2025
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)