NCT06573502

Brief Summary

Studying effectiveness of prp with prf comparing with prp or prf for mangement of tmj osteoarthritis as result in pain and mandibular movement in adult pt

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
42

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Mar 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 31, 2024

Completed
27 days until next milestone

First Posted

Study publicly available on registry

August 27, 2024

Completed
7 months until next milestone

Study Start

First participant enrolled

March 29, 2025

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 29, 2025

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 16, 2025

Completed
Last Updated

December 12, 2025

Status Verified

December 1, 2025

Enrollment Period

6 months

First QC Date

July 31, 2024

Last Update Submit

December 5, 2025

Conditions

Osteoarthritis

Outcome Measures

Primary Outcomes (1)

  • Pain severty

    Visual analog scale measure for pain most sever pain take 10 minimum pain take 0

    6 months

Secondary Outcomes (1)

  • Maximum mouth opening

    6 months

Study Arms (3)

prp with prf group

EXPERIMENTAL

Pt will recievd prp with prf

Combination Product: Prp with prf or prp or prf

prp group

ACTIVE COMPARATOR

Pt will recieve prp only

Combination Product: Prp with prf or prp or prf

prf group

EXPERIMENTAL

Pt will recieve prf only

Combination Product: Prp with prf or prp or prf

Interventions

Prp with prf or prp or prfCOMBINATION_PRODUCT

Combination

prf groupprp groupprp with prf group

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Adult pt with OA

You may not qualify if:

  • Medicaly compromised

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cairo university

Cairo, Egypt

Location

MeSH Terms

Conditions

Osteoarthritis

Interventions

Pituitary Adenylate Cyclase-Activating PolypeptideProlactin-Releasing Hormone

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Intervention Hierarchy (Ancestors)

Nerve Growth FactorsIntercellular Signaling Peptides and ProteinsPeptidesAmino Acids, Peptides, and ProteinsNeuropeptidesProteinsNerve Tissue ProteinsBiological FactorsHypothalamic HormonesPeptide HormonesHormonesHormones, Hormone Substitutes, and Hormone Antagonists

Study Officials

  • Hassan Ab Ghany, Prof

    Cairo University

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
principal investigator

Study Record Dates

First Submitted

July 31, 2024

First Posted

August 27, 2024

Study Start

March 29, 2025

Primary Completion

September 29, 2025

Study Completion

November 16, 2025

Last Updated

December 12, 2025

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)