Development, Standardisation and Standardisation Project for a New Memory Assessment

NCT06564779 | Recruiting

• 1 other identifier: DR240067-NEM
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Episodic memory (EM) is a neuropsychological marker of Alzheimer's disease (AD) (Thomas-Anterion, 2006). Current tests for its assessment do not take into account the identity and emotional aspects of memory (Van der Linden et al., 2018). However, there are models that integrate links with identity, self-awareness and experience. Pause et al. (2013) propose criteria to create ecological tools, including consideration of the emotional valence of memories and the spatio-temporal context of acquisition. In line with these criteria, we have developed a new tool: the NEM (New evaluation of Episodic Memory). Preliminary studies show different response profiles on the NEM among patients (Launay et al., 2023). We now want to evaluate the relevance of this tool in the differential diagnosis of AD.

Conditions

Memory Disorders

Keywords

Alzheimer; Episodic memory

Outcome Measures

Primary Outcomes (1)

• Score total NEM (new memory assessment)

  Sum of the episodic elements

  baseline

Secondary Outcomes (3)

• NEM sub-scores

  baseline

• Total RL/RI 16 Recall

  baseline

• Delayed Mem Logic Recall

  baseline

Study Arms (1)

group intervention

patients benefiting from the new memory assessment

Other: New memory assessment

Interventions

New memory assessment OTHER

The intervention is part of the neuropsychological assessment carried out as part of routine care. It consists of carrying out the neuropsychological tests traditionally used to investigate the diagnostic hypothesis of Alzheimer's disease.

group intervention

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient attending a memory consultation for suspected Alzheimer's disease.

You may qualify if:

• Age ≥ 50 years
• Ability to understand judged sufficient by the assessor;
• Amnesic MCI profile (Petersen, 2003) during the 1st medical consultation prior to the assessment being prescribed.

You may not qualify if:

• Severe auditory and/or visual sensory impairment not compatible with neuropsychological assessment;
• Judged fit to take the test by the assessor;
• Patient under guardianship, curatorship or family guardianship;
• Opposition to data processing.

Sponsors & Collaborators

• University Hospital, Tours: lead

Study Sites (1)

University hospital

Tours, 37044, France

RECRUITING

MeSH Terms

Conditions

Memory Disorders

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Alix LAUNAY

  Tours University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Alix LAUNAY

CONTACT

0247470458; a.launay@chu-tours.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 19, 2024
• First Posted: August 21, 2024
• Study Start: November 22, 2024
• Primary Completion (Estimated): November 1, 2028
• Study Completion (Estimated): November 1, 2028
• Last Updated: April 30, 2026

Record last verified: 2026-04

Locations

FR (1)