Mortality and Cardiovascular Diseases in Adult-onset Type 1 Diabetes
Cardiovascular Disease, Mortality and Prognostic Factors in Adult-onset Type 1 Diabetes
1 other identifier
observational
900,000
1 country
1
Brief Summary
Scarce evidence is available for prognosis in adult-onset type 1 diabetes (T1D). The aim of this study is to investigate the risk of all-cause mortality, cause-specific mortality, and incident CVD in adult-onset T1D, as compared to type 2 diabetes with comparable age at diagnosis and population controls. We will explore potential modifiable factors including lifestyle and clinical characteristics that contribute to T1D prognosis. In addition, we will estimate the life expectancy associated with different age at T1D diagnosis as compared to population controls. This study will be based on people with diabetes recorded in Swedish National Diabetes Registers, with linkages to other nationwide registers to retrieve data on lifestyle factors, biomarkers, treatment and outcome information.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2024
CompletedFirst Submitted
Initial submission to the registry
August 19, 2024
CompletedFirst Posted
Study publicly available on registry
August 20, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2025
CompletedApril 3, 2025
March 1, 2025
1.4 years
August 19, 2024
March 29, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
mortality and vascular outcomes
all-cause mortality, cause-specific mortality, and MACE
2001-2022
Study Arms (3)
population controls
Randomly sampled diabetes controls from the general Swedish population
adult-onset T1D
people who developed T1D as adults 2001-2020 in Sweden
T2D
people who developed T2D 2001-2020 in Sweden
Interventions
We are comparing mortality and vascular outcomes in adult-onset T1D to T2D and diabetes-free people
Eligibility Criteria
the source population was everyone born 2001-2020
You may qualify if:
- people with adult-onset (≥18 years) T1D diagnosed in 2001-2020 from the National Diabetes Register
- all T2D cases diagnosed at age ≥18 years in 2001-2020 recorded in the National Diabetes Register
- Everyone with T1D was matched by age, sex, and county to 50 population controls from the Total Population Register.
You may not qualify if:
- To avoid diabetes secondary to pancreatic cancer, we excluded people diagnosed with cancer in the digestive system 1 year prior to diabetes diagnosis and with pancreatic cancer as the underlying cause of death.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Karolinska institute
Stockholm, 17177, Sweden
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sofia Carlsson, phd
sofia carlsson, senior lecturer, Karolinska Institutet
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 22 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- senior lecturer
Study Record Dates
First Submitted
August 19, 2024
First Posted
August 20, 2024
Study Start
January 1, 2024
Primary Completion
May 31, 2025
Study Completion
July 1, 2025
Last Updated
April 3, 2025
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share
Our data is register-based data that is pseudonymised and thus subject to General Data Protection Regulation (GDPR) and cannot be shared openly