NCT06560970

Brief Summary

Older people with HIV (OPH) often live with significant mental health challenges such as social isolation, loneliness, and depression. The objectives of this study are to develop and test the usability and feasibility of a technology-based psychosocial intervention program designed to: enhance social engagement and support; facilitate resource access and education; reduce loneliness; and improve well-being among older adults with HIV who are long-term survivors (diagnosed with HIV ≥ 20 years). The program, Connecting Older Positive People to Enhance Health and Resilience (COPPEhR), will build on Dr. Sara Czaja's PRISM (A Personal Reminder and Information Management System for Seniors) platform, and will be an easy-to-use software application (app), preloaded onto a standard device, designed to support social connectivity, memory, and access to resources for older adults at risk for isolation and the programs and services available at the Center for Special Studies (CSS) at Weill Cornell Medicine (WCM). This protocol covers Phase 2 of the study, which will be a pilot randomized controlled efficacy trial will compare the COPPEhR intervention to a device-only control condition. Participants in the control condition will receive the same device as those in the COPPEhR condition without the COPPEhR application. The specific aims of this developmental project are to evaluate the feasibility, usefulness, and usability of a state-of-the art technology-based multicomponent COPPEhR intervention for aging adults with HIV. Our hypothesis is the COPPEhR intervention will be feasible, usable and useful. The hypothesis is that those that use the COPPEhR app will experience less loneliness, less depression, and less social isolation and more social support, more resilience, and more connectivity than those that do not use the COPPEhR app.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
68

participants targeted

Target at P50-P75 for not_applicable

Timeline
2mo left

Started Dec 2024

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress92%
Dec 2024May 2026

First Submitted

Initial submission to the registry

August 15, 2024

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 19, 2024

Completed
4 months until next milestone

Study Start

First participant enrolled

December 12, 2024

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2026

Last Updated

April 16, 2026

Status Verified

April 1, 2026

Enrollment Period

1.5 years

First QC Date

August 15, 2024

Last Update Submit

April 14, 2026

Conditions

Keywords

TechnologyComputerSocial EngagementWell-beingOlder Adults

Outcome Measures

Primary Outcomes (2)

  • Mean Difference of Perceived Usefulness and Perceived Ease of Use Questionnaire

    Utilizing a 12-item scale (Perceived Ease of Use Questionnaire) which includes two subscales (perceived usefulness and perceived ease of use) with Likert response scales ranging from 1 (Strongly disagree) - 7 (Strongly agree). The total score ranges from 12 - 84. The responses to the items are summed for each of the subscales. Higher scores indicate perceived ease of use of the COPPEhR program.

    Post-randomization at month 3 and month 6

  • Mean Difference of System Evaluation Questionnaire

    The COPPEhR system or device evaluation will be assessed by evaluating participants' perception of the features of the system. Utilizing an 11-item scale with Likert response scales ranging from 1 (Strongly disagree) - 5 (Strongly agree). The total score ranges from 11 - 55. Higher scores indicate higher degrees of satisfaction with the COPPEhR system, training, technical support.

    Post-randomization at month 3 and month 6

Secondary Outcomes (9)

  • Mean Difference in Score of reported depression, assessed using the Center for Epidemiological Studies-Depression (CES-D) Scale

    Post-randomization at Baseline, month 3, and month 6

  • Change in Loneliness as Measured by UCLA Loneliness Scale

    Post-randomization at Baseline, month 3, and month 6

  • Mean Difference in Score of Quality of Life, assessed using The Quality of Life Questionnaire

    Post-randomization at Baseline, month 3, and month 6

  • Mean Difference in score of participants self-reported health, assessed using the 36-Item Short Form Health Survey questionnaire (SF-36 Short Form)

    Post-randomization at Baseline, month 3, and month 6

  • Mean Difference in score of participants self-reported Resilience, assessed by BRS - Brief Resilience Scale

    Post-randomization at Baseline, month 3, and month 6

  • +4 more secondary outcomes

Study Arms (2)

COPPEhR Intervention

EXPERIMENTAL

Participants will have access to the COPPEhR system which will provide social support and engagement among older adults diagnosed with HIV.

Behavioral: COPPEhR Intervention

Device-only Control Condition

PLACEBO COMPARATOR

Participants will have access to a device only without the COPPEhR system.

Behavioral: Device-only Control Condition

Interventions

Participants will receive access to the COPPEhR system which will provide social support and engagement among older adults diagnosed with HIV.

COPPEhR Intervention

Participants will have access to a device only without the COPPEhR system.

Device-only Control Condition

Eligibility Criteria

Age50 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 50+
  • HIV diagnosis for at least 15 years
  • Center for Special Studies (CSS) patient
  • Able to read English at 6th grade level
  • Visually able to read a device screen
  • Adequate cognitive status (score above 34) to interact with the technology assessed by the Telephone Interview for Cognitive Status - modified (TICS-M)
  • Plan to remain in the area for the next 9 months

You may not qualify if:

  • Not a Center for Special Studies (CSS) patient
  • Blind or have visual impairments that limit their ability to view the technology
  • Deaf or have hearing impairments that limit their ability to use the technology
  • Has a mobility or dexterity impairment that would interfere with the use of a device, mouse, or a keyboard (e.g., tremors, arthritis, etc.)
  • Severe psychosis (e.g., aggression)
  • Severe cognitive impairment that limits their ability to use the technology
  • Participants in previous COPPEhR usability testing

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Weill Cornell Medicine

New York, New York, 10065, United States

Location

Study Officials

  • Sara Czaja, PhD

    Weill Medical College of Cornell University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Masking Details
The participants will be blind to their assigned condition.
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 15, 2024

First Posted

August 19, 2024

Study Start

December 12, 2024

Primary Completion (Estimated)

May 31, 2026

Study Completion (Estimated)

May 31, 2026

Last Updated

April 16, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

The investigators plan for resource sharing is based on the National Institutes of Health/National Institute on Aging (NIH/NIA) Data Sharing Policy. The investigators plan, consistent with the NIH goals of data sharing, is to promote use of the rich COPPEhR database by the larger research community as this will further the impact of COPPEhR and expand possibilities for collaboration. It will also allow other researchers to expedite the translation of the research findings into knowledge, products, and procedures. Further, the plan is devised to make the data as widely and freely available as possible while at the same time safeguarding the privacy of participants and protecting confidential and proprietary data.

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
Time Frame
The data from research projects will be made available no later than acceptance of publication of the main findings from the final data set. There is no end date to access the data from the research projects.
Access Criteria
The investigators agree to share the data with researchers working under an institution with Federal Wide Assurance who agree to a data sharing agreement that stipulates protection of participant privacy and data confidentiality, acknowledgement of COPPEhR, that the data will be used for research purposes only, and that the data will not be transferred to other users. The computerized data will include raw data, derived variables, all necessary documentation as described in the National Archive of Computerized Data on Aging depositor agreement. All data will be de-identified. The investigators will follow the guides published by the US Department of Health and Human Services in this respect. Each data set will include data documentation to ensure that others can use the data set and to minimize confusion. Information about where and how to locate and access the data will be available in any publications and presentations authored by COPPEhR investigators.

Locations