Regulation of HIIT Combined with IET on Vascular Function in Young Women with Normal Weight Obesity

NCT06556875 | Completed

• 1 other identifier: RHCIVFYWNWO
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Comparison of the effects of combined IET with HIIT and HIIT on vascular function in young NWO women.

Conditions

Normal Weight Obesity

Keywords

isometric exercise training; high-intensity interval training; normal weight obesity; vascular fitness

Outcome Measures

Primary Outcomes (2)

• Intima-Media Thickness (IMT)

  The subjects were required to sit still for 5～10 minutes before the test, and the carotid artery structural and functional parameters were recorded using a GE vivid 7 colour ultrasound instrument from the United States as follows: the subjects were required to lie in the supine position, and the probe was used to sweep longitudinally along the outer edge of the sternocleidomastoid muscle, and the maximal Intima-media thickness (IMT) was measured. Changes in Intima media thickness before and after intervention.

  8 weeks

• Flow-Mediated Dilation (FMD)

  Vascular endothelial function was measured with a Japanese-made UNEX EF vascular endothelial function tester. Pressure was applied on top of the resting blood pressure and the ischaemic process was performed for 5 min. At the end of the ischaemic process, the pressure band was removed and flow-mediated dilation (FMD) of the brachial artery was calculated. Changes in Flow-mediated dilation before and after Intervention

  8 weeks

Secondary Outcomes (5)

• Body Composition Indicators

  8 weeks

• Body Mass Index (BMI)

  8 weeks

• Blood Pressure (BP)

  8 weeks

• Pulse Wave Velocity (PWV) and ankle brachial index (ABI)

  8 weeks

• Volume Oxygen Maximum (VO2max)

  8 weeks

Study Arms (3)

HIIT group

ACTIVE COMPARATOR

Behavioral: HIIT

HIIT combined IET group

ACTIVE COMPARATOR

Behavioral: HIIT combined IET

Control group

NO INTERVENTION

Interventions

HIIT BEHAVIORAL

high intensity interval training

HIIT group

HIIT combined IET BEHAVIORAL

high intensity interval training combined with isometric exercise training

HIIT combined IET group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Female, aged between 18 and 30 years old;
• BMI between 18.5 and 24.9 kg/m2 with a BF% \> 30% (normal weight obesity determination criteria);
• exercise capacity to complete the exercise programme.

You may not qualify if:

• Acute or chronic musculoskeletal disorders, cardiovascular diseases, etc. that prevented training;
• other diseases (such as diabetes, etc.) that had a great impact on physical condition;
• bad habits (such as smoking, drinking, etc.);
• and unstable body weight (up and down fluctuations of more than 2.5 kg) in the 3 months before the experiment.

Sponsors & Collaborators

• Beijing Sport University: lead

Study Sites (1)

School of Sports Medicine and Rehabilitation, Beijing Sport University

Beijing, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 27, 2024
• First Posted: August 16, 2024
• Study Start: February 23, 2023
• Primary Completion: September 30, 2023
• Study Completion: December 30, 2023
• Last Updated: October 28, 2024

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)