Evaluation of a Predictive Score for the Onset of Moderate to Severe Alcohol Withdrawal Syndrome, the PAWSS, in a Population of Intensive Care Patients at Brest University Hospital

NCT06555679 | Completed DMC

• 1 other identifier: 29BRC22.0126 PAWSS-ICU
• Study Type: observational
• Target: 403
• Locations: 1 country
• Sites: 1

Brief Summary

alcohol use disorder (AUD) is a very common condition in patients admitting in ICU's. Brutal stop of alcohol consumption may lead to a withdrawal syndrome, wich is associated with a worse outcome for ICU patients (longuer ICU and hospital stays, use of mechanical ventilation, traumas). The aim of this study is to valid a score (PAWSS : prediction of alcohol withdrawal syndrome (AWS) scale) to predict at admission mild to severe AWS in ICU patients population.

Conditions

Alcohol Withdrawal Syndrome

Keywords

prediction; intensive care unit

Outcome Measures

Primary Outcomes (1)

• Evaluation of PAWSS statistic performances to predict AWS in ICU patients

  Evaluation of sensitivity, specificity, positive and negative predictive values of PAWSS to predict moderate or severe AWS (defined by a CIWA greater than or equal to 8)

  the first 5 days of hospital stay

Secondary Outcomes (1)

• Creation of a new score, the PAWSS-ICU, able to predict AWS in ICU patients

  during ICU stay

Other Outcomes (1)

• Evaluation of alcohol use disorders (AUD) ans AWS in our population

  during ICU stay

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

ICU patients

You may qualify if:

• more than 18 years old
• able to answer to PAWSS in the first 48hours of ICU stay

You may not qualify if:

• No alcohol consumption in the last 30 days
• hospital stay of more than 5 days at ICU admission
• hospital stay less than 5 days in total
• expected sedation time of more than 48h
• patient not able to understand the PAWSS
• no consent

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

CHRU Brest

Brest, 29200, France

Location

Related Publications (1)

• Wood E, Albarqouni L, Tkachuk S, Green CJ, Ahamad K, Nolan S, McLean M, Klimas J. Will This Hospitalized Patient Develop Severe Alcohol Withdrawal Syndrome?: The Rational Clinical Examination Systematic Review. JAMA. 2018 Aug 28;320(8):825-833. doi: 10.1001/jama.2018.10574.

  PMID: 30167704 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 8, 2024
• First Posted: August 15, 2024
• Study Start: June 27, 2022
• Primary Completion: June 26, 2023
• Study Completion: June 26, 2023
• Last Updated: August 15, 2024

Record last verified: 2024-08

Locations

FR (1)