Epidemiological Study of the Markers of Aging in the Cohort of Patient HIV in Brest

NCT06554210 | Completed

• 1 other identifier: VIHVA 2016.CE31
• Study Type: observational
• Target: 213
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: HIV pathology has been associated with accelerated aging of the infected organism, with no known knowledge of virus, immunosuppression, immune response stimulation, antiretroviral toxicity, and "classic" risks. The data are in good standing from a multicenter cohort with high statistical power but very heterogeneous and not exhaustive. A complementary approach by small, comprehensive cohorts is desirable. POPULATION CONCERNED: HIV-positive persons OBJECTIVE To describe the aging of the physiological functions of people living with HIV. SECONDARY OBJECTIVES Assess the determinants (virus / HAART / Immunity / environment) Compare to the general population (historical comparisons) Compare to main body functions MAIN EVALUATION CRITERIA respiratory functional tests, memory test, IMTc, ECG, creatininemia, cancer, Fibroscan, bone densitometry... SECONDARY EVALUATION CRITERIA Age, sex, phototype, CD4 lymphocytes count, viral load, nadir CD4, antiretroviral exposure, alcohol, tobacco ... METHODOLOGY Monocentric retrospective study STATISTICS Frailty model, chi2 test, test U INCLUSION CRITERIA Seropositive for HIV, age\>18 years Follow-up at least once in the Internal Medicine department between 1995 and 2018 CRITERIA OF EXCLUSION Refusal of the patient or unreachable patient NUMBER OF PATIENTS Between 200 and 300 CALENDAR Duration of inclusions: 3 months Duration of participation of the patient: 20 years (retrospectives ...) Duration of the study: 1 year

Conditions

Aging, Premature; HIV Infections

Keywords

Aging; HIV

Outcome Measures

Primary Outcomes (7)

• renal aging

  creatinin level, creatinin clearance, microalbuminuria

  yearly

• pulmonary aging

  respiratory functional test

  at last one

• liver aging

  elastometry (Fibroscan\*)

  at last one

• neurological aging

  memory tests

  at last one

• vascular aging

  intima-media thickness, systolic and diastolic blood pressure

  at last one

• Bone aging

  osteodensitometry

  at last one

• heart aging

  ECG, echography

  at last one

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All persons followed between 2003 to 2018 in the one center (Internal Médicine) of the West Brittany cohort

You may qualify if:

• HIV positive persons followed in Internal Medicine departement of Brest University Hospital

You may not qualify if:

• opposition of the study
• \<18 ans

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

Internal Medicine Department of University Hospital

Brest, 29200, France

Location

MeSH Terms

Conditions

Aging, Premature; HIV Infections

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Study Officials

• Luc de Saint-Martin, MD, PhD

  University Hospital, Brest

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 1, 2018
• First Posted: August 15, 2024
• Study Start: January 8, 2017
• Primary Completion: December 31, 2017
• Study Completion: December 31, 2017
• Last Updated: August 15, 2024

Record last verified: 2024-08

Locations

FR (1)