Analysis of Protein Expression in Serum of KOA Subjects
1 other identifier
interventional
50
1 country
1
Brief Summary
In the previous study "Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113)", we found that acupuncture for knee osteoarthritis(KOA) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. However, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. To analyze the protein expression in the serum of KOA control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from Ryodoraku. The results obtained can be compared with previous studies, thus this experiment was designed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable knee-osteoarthritis
Started Aug 2024
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 4, 2024
CompletedStudy Start
First participant enrolled
August 4, 2024
CompletedFirst Posted
Study publicly available on registry
August 14, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 23, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
July 23, 2025
CompletedAugust 14, 2024
August 1, 2024
12 months
August 4, 2024
August 11, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Micro-Western Array and Enzyme-linked immunosorbent assay
Obtaining the serum protein content value
the first and the fifth weeks
Secondary Outcomes (1)
pulse sphygmograph and Ryodoraku
the first and the fifth weeks
Study Arms (1)
the control group of knee arthritis
OTHERMonitoring the stability of protein expression, pulse wave and meridian energy in the serum of the KOA control group (participants without knee pain).
Interventions
The subjects first took the energy measurement of the pulse sphygmograph and Ryodoraku, rested for 20 minutes, and then repeated the measurements again. In order to comply with the acupuncture treatment course was 5 weeks in the previous study, we have two blood draw point. Each subject's blood was drawn for the first time, and then for the second time in 5 weeks later. Each subject drew 10ml of blood each time. The blood samples are analyzed by Micro-Western Array (MWA) and Enzyme-linked immunosorbent assay (ELISA) to obtain the serum protein content value of healthy individuals.
Eligibility Criteria
You may qualify if:
- Adults over 50 years old without knee pain
You may not qualify if:
- Clinical diagnosis of knee osteoarthritis
- Taking anti-inflammatory and analgesic drugs in the past month
- Taking blood-lipid-lowering drugs or health foods in the past month
- Received any acupuncture treatment in the past 3 weeks
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
China Medical University
Taichung, Taiwan
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Wan-Zhen Yu
China Medical University, China
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 4, 2024
First Posted
August 14, 2024
Study Start
August 4, 2024
Primary Completion
July 23, 2025
Study Completion
July 23, 2025
Last Updated
August 14, 2024
Record last verified: 2024-08