NCT06549101

Brief Summary

In the immune system, it has been observed that the preoperative neutrophil-to-lymphocyte ratio (NLR) is an index that reflects the state of inflammation and oxidative stress. In the perioperative period, NLR has been described as a predictor for patients who will develop renal injury, ischemic stroke, and myocardial injury. Since preoperative inflammation is a predictor of morbidity and mortality in patients undergoing non-cardiac surgery, a retrospective analysis of the inflammatory status of patients undergoing surgery at the center is proposed.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
851

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 23, 2022

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2023

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

August 7, 2024

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 12, 2024

Completed
Last Updated

December 16, 2024

Status Verified

August 1, 2024

Enrollment Period

1.3 years

First QC Date

August 7, 2024

Last Update Submit

December 11, 2024

Conditions

Emergency Surgery

Keywords

Neutrophil-to-lymphocyte ratioEmergency surgeryNLR

Outcome Measures

Primary Outcomes (2)

  • NLR

    Preoperative neutrophil-to-lymphocyte ratio

    Day of surgery

  • Mortality

    30 and 180 days mortality

    6 months after surgery

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Emergency patients operated on at the Clinical Hospital of the University of Chile between January and December 2021

You may qualify if:

  • Availability of complete blood count in electronic medical records of all patients operated on between January and December 2021

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital Clínico de la Universidad de Chile

Santiago, Santiago Metropolitan, 8380456, Chile

Location

Related Publications (1)

  • Maldonado F, Albornoz M, Enriquez I, Espinoza C, Chang H, Carrasco L, Diaz-Papapietro C, Medina F, Gonzalez R, Caceres M. Association of neutrophil-to-lymphocyte ratio with age and 180-day mortality after emergency surgery. BMC Anesthesiol. 2024 Sep 17;24(1):329. doi: 10.1186/s12871-024-02718-z.

    PMID: 39289610DERIVED

Study Officials

  • Felipe Maldonado, M.D., M. Sc.

    Hospital Clínico de la Universidad de Chile

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 7, 2024

First Posted

August 12, 2024

Study Start

September 23, 2022

Primary Completion

December 30, 2023

Study Completion

December 30, 2023

Last Updated

December 16, 2024

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will not share

Locations

CL(1)