Vitamin D Supplementation in Critically Ill Children With Respiratory Diseases

NCT06547749 | Not Yet Recruiting

• 1 other identifier: Vitamin D supplementation
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the role of vitamin D supplementation in critically ill children with respiratory diseases regarding their outcome.

Conditions

Vitamin D Supplementation

Outcome Measures

Primary Outcomes (2)

• Hospital length of stay

  How long the patient will stay in Hospital

  Baseline

• Ventilator free day

  How long is the free days

  Baseline

Eligibility Criteria

• Age: 1 Month - 16 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

pediatric patients admitted in PICU with respiratory disease

You may qualify if:

• All pediatric patients admitted in PICU with respiratory disease with age from 1month to 16 years.

You may not qualify if:

• Patients admitted in PICU due to causes rather than respiratory disease.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Triantos C, Aggeletopoulou I, Mantzaris GJ, Mouzaki A. Molecular basis of vitamin D action in inflammatory bowel disease. Autoimmun Rev. 2022 Aug;21(8):103136. doi: 10.1016/j.autrev.2022.103136. Epub 2022 Jul 2.

  PMID: 35792343 BACKGROUND

• Vanichkulbodee A, Romposra M, Inboriboon PC, Trongtrakul K. Effects of vitamin D insufficiency on sepsis severity and risk of hospitalisation in emergency department patients: a cross-sectional study. BMJ Open. 2023 Jan 17;13(1):e064985. doi: 10.1136/bmjopen-2022-064985.

  PMID: 36653058 BACKGROUND

• Han JE, Jones JL, Tangpricha V, Brown MA, Brown LAS, Hao L, Hebbar G, Lee MJ, Liu S, Ziegler TR, Martin GS. High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial. J Clin Transl Endocrinol. 2016 Jun;4:59-65. doi: 10.1016/j.jcte.2016.04.004. Epub 2016 May 5.

  PMID: 27419080 BACKGROUND

• He M, Cao T, Wang J, Wang C, Wang Z, Abdelrahim MEA. Vitamin D deficiency relation to sepsis, paediatric risk of mortality III score, need for ventilation support, length of hospital stay, and duration of mechanical ventilation in critically ill children: A meta-analysis. Int J Clin Pract. 2021 Apr;75(4):e13908. doi: 10.1111/ijcp.13908. Epub 2020 Dec 20.

  PMID: 33280208 BACKGROUND

• Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011 Jan;96(1):53-8. doi: 10.1210/jc.2010-2704. Epub 2010 Nov 29.

  PMID: 21118827 BACKGROUND

Central Study Contacts

Mohamed Ali

CONTACT

01284871896; abo.alimai.123@gmail.com

Azza Eltyeb, Professor

CONTACT

0 1006863277; azeltyeb@aun.eud.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: August 2, 2024
• First Posted: August 9, 2024
• Study Start: December 1, 2025
• Primary Completion (Estimated): November 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: September 23, 2025

Record last verified: 2025-09