Dietary Intervention on Atopy

NCT06547372 | Recruiting

• 1 other identifier: NUS-IRB-2024-28
• Study Type: interventional
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

Diet is a key determinant of overall health, with growing evidence associating dietary patterns with allergic diseases. Among these, atopic dermatitis (AD) is of particular interest as it often represents the earliest manifestation of the atopic triad. Investigating dietary interventions in AD therefore provides a relevant model to better understand how diet may influence the onset and progression of allergic disease more broadly.

Conditions

Atopic; Allergic Diseases; Allergic Rhinitis; Atopic Dermatitis

Keywords

Atopic dermatitis; My Healthy Eating Plate; eczema; healthy diet; diet; meals; foods; allergic; allergy; atopic; Singapore; nutrients

Outcome Measures

Primary Outcomes (1)

• Healthy Dietary Intervention in Treating Atopic Dermatitis (Reducing SCORAD Scores)

  This study evaluates whether a dietary pattern lower in saturated fats and higher in whole grains, fruits, and vegetables reduces AD severity in young Singaporean adults over a 2-month period, as measured by changes in Scoring Atopic Dermatitis (SCORAD) scores. The SCORAD index is a validated measure of AD severity that integrates lesion extent, clinical signs (erythema, edema, oozing/crusting, excoriation, lichenification, dryness), and patient-reported symptoms. It quantifies affected body surface areas (e.g., head, limbs, trunk), enabling standardized baseline assessment and sensitive monitoring of changes over time.

  Baseline, 2 months (intervention period), and 1 month post-intervention follow-up

Secondary Outcomes (8)

• Change in skin barrier function assessed by bioengineering measures

  Baseline, 2 months (intervention period), and 1 month post-intervention follow-up

• Change in dermatology-specific quality of life (DLQI)

  Baseline, 2 months (intervention period), and 1 month post-intervention follow-up

• Change in atopic dermatitis-related medication utilisation

  Baseline, 2 months (intervention period), and 1 month post-intervention follow-up

• Height and Weight Measurements

  Baseline, 2 months (intervention period), and 1 month post-intervention follow-up

• Blood Pressure Measurement

  Baseline, 2 months (intervention period), and 1 month post-intervention follow-up

Study Arms (2)

Intervention

EXPERIMENTAL

Throughout the 2-month intervention period, only participants in the intervention arm will be provided with bento-styled meals for lunch and dinner daily. The meals will encompass a variety of nutrient-rich ingredients, including whole grains, lean proteins, an array of fruits and vegetables, and healthy fats. The food will be prepared by a licensed food catering service.

Other: Dietary Intervention on Atopy

Control

NO INTERVENTION

The control group will not receive the meals provided by our study nor will they receive any nutritional advice. Instead, they will continue following their usual dietary habits and patterns throughout the study period.

Interventions

Dietary Intervention on Atopy OTHER

The primary aim of this dietary intervention study is to assess the effectiveness of a dietary pattern characterized by lower saturated fats, higher wholegrains, fruit, and vegetables in reducing the severity of AD in young Singapore adults, as measured by changes in Scoring Atopic Dermatitis (SCORAD) scores, over a 2-month intervention period.

Intervention

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Presence of current, mild-to-moderate atopic dermatitis/eczema at flexural areas
• to 65 years of age (inclusive) at screening
• Must be English-literate and able to give informed consent in English
• Be residing in Singapore and will not be travelling outside of Singapore during the study period
• Reliable and willing to follow study procedures and be available for the duration of the study
• Non-smokers (tobacco and e-cigarette)
• Non-drinker (no regular or frequent consumption of alcohol)
• Overtly healthy with no pre-existing medical conditions (e.g., diabetes, hypertension, cancer, blood disorders, degenerative/liver/autoimmune/immune/renal diseases, or psychiatric conditions)
• No food allergies to test foods
• No needle phobia
• Be willing to follow the instruction provided by the investigators on the use of any moisturiser, cosmetics, and/or topical cream on the skin throughout the entire duration of the study.

You may not qualify if:

• Concurrent participation in other research studies
• Pregnancy or lactating individuals
• Known or ongoing psychiatric disorders within 3 years
• Known severe nutritional deficiency
• Vegetarian/vegans (as meat will be included in the diet)
• Individuals who made a significant dietary change in the past 12 months
• Having a pre-existing dietary restriction that would interfere with the adherence to a whole diet meal
• Regular use of strong medication (western and/or traditional), therapies, and alternative medications
• Regular nutritional supplements in the past 12 months Regular consumption of oral contraceptive pills and/or steroid hormones
• Antibiotic use in the past 2 months
• Any long-term hospitalisation or surgery during the 6 months before enrolment in study
• Significant change in weight (+/- 5.0%) during the past month
• History of bleeding diathesis or coagulopathy (or any bleeding disorders)
• Having donated blood of more than 500 mL within 4 weeks of study enrolment

Sponsors & Collaborators

• National University of Singapore: lead

Study Sites (1)

National University of Singapore

Singapore, Singapore, 118177, Singapore

RECRUITING

MeSH Terms

Conditions

Dermatitis, Atopic; Rhinitis, Allergic; Eczema; Hypersensitivity

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Immune System Diseases; Rhinitis; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases

Study Officials

• Fook Tim CHEW, PhD

  NUS Singapore

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mei Hui Liu, PhD

CONTACT

65163523; fstlmh@nus.edu.sg

Jun Jie Lim, PhD

CONTACT

65161685; limjj@nus.edu.sg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 2, 2024
• First Posted: August 9, 2024
• Study Start: May 10, 2024
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: April 1, 2026

Record last verified: 2025-10

Locations

SG (1)