Music Perception in SeLECTs

NCT06545708 | Recruiting

• 1 other identifier: 69HCL24_0084
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 2

Brief Summary

Self-limited epilepsy with centrotemporal spikes (SeLECTS) is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years. SeLECTS is associated in 15 to 30% of patients with specific cognitive deficits, including in particular disorders in language, visuo-spatial memory, declarative memory, and attention. SeLECTS has the potential to evolve into Landau-Kleffner syndrome, the most extreme form of SeLECTS including symptoms of auditory agnosia and aphasia, with potential risks of persistent neuropsychological impairments. In a recent study in adults who had suffered Landau-Kleffner syndrome during childhood, the investigators have shown that these patients, in addition to their known deficit in verbal short-term memory, also exhibit persistent musical difficulties during adulthood, with in particular deficit in melody and rhythm short-term memory. In the present project, the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by investigating the integrity of music perception, both for melody and rhythm. To date, data about music perception in children with epilepsy are scarce and we do not know how distinct components of melody and rhythm perception and memory may be altered.

Conditions

Rolandic Epilepsy

Keywords

Epilepsy; music; childhood; neurology; rhythm; pitch; language

Outcome Measures

Primary Outcomes (4)

• Performance obtained in melodic tasks

  Comparison between controls and patients using Bayesian ANOVAs to the percentages of correct responses obtained with melodic tasks

  2 Years

• Performance obtained in melodic tasks

  Comparison between controls and patients using Bayesian ANOVAs to response times obtained with melodic tasks;

  2 Years

• Performance obtained in rhythmic tasks

  Comparison between controls and patients using Bayesian ANOVAs to the percentages of correct responses obtained with rhythmic tasks

  2 Years

• Performance obtained in rhythmic tasks

  Comparison between controls and patients using Bayesian ANOVAs to response times obtained with rhythmic tasks.

  2 Years

Study Arms (2)

Patients

This group consists of children and adolescents between the ages of 5 and 14, diagnosed with self-limited epilepsy with centrotemporal spikes by a medical professional (epileptologist or neurologist), and in the active phase of the disorder.

Other: Patients

Controls

This group consists of healthy individuals between 5 and 14 years old, with no history of epilepsy and/or other neurodevelopmental disorders.

Other: Patients

Interventions

Patients OTHER

This group consists of children and adolescents between the ages of 5 and 14, diagnosed with self-limited epilepsy with centrotemporal spikes by a medical professional (epileptologist or neurologist), and in the active phase of the disorder.

Controls; Patients

Eligibility Criteria

• Age: 5 Years - 14 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

The participants will be recruited from a population of 5 to 14 years of age. 50 healthy control participants will be recruited by posting flyers and/or by electronic message, and 50 epileptic patients will be recruited within the HFME child epileptology department (HCL). Their inclusion will be made at the CRNL or HFME by one of the study investigators.

You may qualify if:

• Subject aged between 5 and 14 years old
• Non-opposition of parents or guardians for the child's participation in the study
• No major cognitive impairment and ability to understand and apply instructions
• Subject affiliated to a social security scheme
• Subject motivated to participate in the project
• Proficiency with the French language
• For the group of control participants:
• Without neurological or psychiatric history
• For the group of participants with seizure disorder:
• No neurological (except EPCT) or psychiatric history
• Diagnosis of self-limited epilepsy with centro-temporal spikes (PTSE) by a qualified healthcare professional.

You may not qualify if:

• Major cognitive impairment or inability to understand and apply instructions
• Individuals refusing to participate in the study
• Pregnant or breastfeeding minors

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (2)

Centre Hospitalier Le Vinatier (Bât. 452),

Bron, Bron, 69500, France

NOT YET RECRUITING

Hospices Civils de Lyon

Bron, Bron, 69500, France

RECRUITING

MeSH Terms

Conditions

Epilepsy, Rolandic; Epilepsy; Language

Condition Hierarchy (Ancestors)

Epilepsies, Partial; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Epileptic Syndromes; Communication; Behavior

Central Study Contacts

Maria PAPADOPOULOU, MD

CONTACT

04 27 85 65 78; maria.papadopoulou@chu-lyon.fr

Anne CACLIN, PhD

CONTACT

04.72.13.89.04; anne.caclin@inserm.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 10, 2024
• First Posted: August 9, 2024
• Study Start: November 13, 2024
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: December 9, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)