Performance of Mid-Upper Arm Circumference for Detection of Severe Acute Malnutrition in Indonesian Under-Fives

NCT06545240 | Completed DMC

• 1 other identifier: 19-12-1452
• Study Type: observational
• Target: 421
• Locations: 1 country
• Sites: 2

Brief Summary

WHO recommends 11.5 cm as a cut-off point of Mid-Upper Arm Circumference (MUAC) to detect and/or diagnose severe acute malnutrition (SAM) in under-five. MUAC is practical and useful, especially in area with limited facilities which has no standardized scale and infantometer. However, several studies showed that this cut-off need to be evaluated as it has modest detection rate for SAM. This study aims to evaluate diagnostic value of MUAC with 11.5 cm cut-off compared to WHZ as gold standard to identify SAM. The sensitivity, specificity, positive and negative predictive value of MUAC with 11.5 cm as a standard cut-off will be evaluated. This study also aim to find new cut-off value that may offer better diagnostic performance. The main research questions were: What is the diagnostic accuracy of Mid-Upper Arm Circumference (MUAC) compared to the Weight for Height Z Score (WHZ) in identifying SAM in children, and what is the optimal MUAC cut-off value for enhanced diagnostic performance?

Conditions

Severe Acute Malnutrition

Keywords

mid-upper arm circumference; sensitivity; severe acute malnutrition; specificity; WHZ index

Outcome Measures

Primary Outcomes (1)

• Diagnostic value of MUAC in diagnosing SAM compare to WHZ-index

  To evaluate sensitivity, specificity, positive and negative predictive value of MUAC

  2 months

Secondary Outcomes (1)

• Finding new cut off value that offer better diagnostic performance using ROC

  2 months

Interventions

Mid-upper arm circumference DIAGNOSTIC_TEST

Mid-upper arm circumference was taken using non-stretchable band SECA 202

Also known as: Weight measurement, Length and height measurement

Eligibility Criteria

• Age: 6 Months - 59 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

This study was conducted in the largest primary community health care facility in Cengkareng Jakarta and have 29.110 registered under-fives in its service area.

You may qualify if:

• under-fives that 6-59 months-old

You may not qualify if:

• ascites
• edema
• hydrocephalus
• tumor or oncologic diseases
• organomegaly
• uncooperative during measurement

Sponsors & Collaborators

• Indonesia University: lead

Study Sites (2)

Puskesmas Cengkareng

Jakarta, DKI Jakarta, 11730, Indonesia

Location

RSUPN Dr Cipto Mangunkusumo

Jakarta Pusat, DKI Jakarta, 10440, Indonesia

Location

MeSH Terms

Conditions

Severe Acute Malnutrition; Hypersensitivity

Condition Hierarchy (Ancestors)

Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 31, 2024
• First Posted: August 9, 2024
• Study Start: January 1, 2020
• Primary Completion: February 29, 2020
• Study Completion: February 29, 2020
• Last Updated: August 9, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

ID (2)