Effect of Transcranial Direct Current Stimulation on the Voice

NCT06544122 | Completed

• 1 other identifier: TDCS_voice
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to verify the effect on the voice of transcranial direct current stimulation (tDCS) in vocally healthy non-singers. The main question it aims to answer is: What is the brain area in which tDCS promotes better vocal performance in vocally healthy individuals? Each participants received anodal tDCS applied at an intensity of 2 mA for a duration of 20 minutes for tDCS stimulations in different areas with a 7-day washout period between stimulations. Vocal assessments was conducted before and after the intervention. The targeted places were the primary motor cortex (M1), primary somatosensory cortex (S1), Cerebellum, and dorsolateral prefrontal cortex (DLPFC).

Conditions

Voice and Resonance Disorders; Transcranial Direct Current Stimulation; Voice Disturbance

Keywords

transcranial direct current stimulation; voice; speech therapy

Outcome Measures

Primary Outcomes (1)

• Vocal range profile

  Min f0 (Hz) Max f0 (Hz) Ext f0 (Hz) Ext (ST) Mín int (dB) Max int (dB) Area (%) Min f0 (Hz) Max f0 (Hz) Ext f0 (Hz) Ext (ST) Mín int (dB) Max int (dB) Area (%) Minimum f0 (Hz); Maximum f0 (Hz); Extension f0; Extension in St; Minimum intensity (dB); Maximum intensity (dB); Area (%)

  through study completion, an average of 6 months

Secondary Outcomes (3)

• Voice

  through study completion, an average of 6 months

• Laryngeal diadochokinesis

  through study completion, an average of 6 months

• Vocal effort

  through study completion, an average of 6 months

Study Arms (4)

Effects on voice of M1 tDCS in healthy voice volunteers

ACTIVE COMPARATOR

The aim of this arm is to verify the effect on the voice of anodal tDCS M1 larynx target.

Device: Transcranial direct current stimulation

Effects on voice of S1 tDCS in vocally health volunteers

ACTIVE COMPARATOR

The aim of this arm is to verify the effect on the voice of anodal tDCS S1 larynx target.

Device: Transcranial direct current stimulation

Effects on voice of PFDLC tDCS in vocally health volunteers

ACTIVE COMPARATOR

The aim of this arm is to verify the effect on the voice of anodal tDCS PFDLC target.

Device: Transcranial direct current stimulation

Effects on voice of cerebellum tDCS in vocally health volunteers

ACTIVE COMPARATOR

The aim of this arm is to verify the effect on the voice of anodal tDCS cerebellum target.

Device: Transcranial direct current stimulation

Interventions

Transcranial direct current stimulation DEVICE

Anodal tDCS will be applied at an intensity of 2mA and duration of 20 minutes. The assembly of the electrodes during the tDCS sessions will be carried out as follows: primary motor cortex, the stimulation electrode (anode) will be positioned on C5 (international EEG 10-20 system), in S1 (2cm posterior to C5), at the PFCDL (Fp3), all with the cathode positioned on the region contralateral supraorbital. For cerebellar tDCS the anode will be positioned on the inion area and the cathode on the deltoide muscle.

Also known as: tDCS, transcranial electrical stimulation, anodal stimulation tDCS

Effects on voice of M1 tDCS in healthy voice volunteers; Effects on voice of PFDLC tDCS in vocally health volunteers; Effects on voice of S1 tDCS in vocally health volunteers; Effects on voice of cerebellum tDCS in vocally health volunteers

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Non-singers with healthy voice

You may not qualify if:

• Smokers
• Those who present signs and symptoms of laryngeal, pharyngeal or respiratory diseases at the time of collection
• Volunteers who make regular use of neuroactive drugs
• Those who have metallic implants or a pacemaker
• People that have any history of seizures or epilepsy

Sponsors & Collaborators

• Universidade Federal de Pernambuco: lead

Study Sites (1)

Laboratório de Neurociência Aplicada

Recife, Pernambuco, 50740-560, Brazil

Location

Related Publications (6)

• Behroozmand R, Johari K, Bridwell K, Hayden C, Fahey D, den Ouden DB. Modulation of vocal pitch control through high-definition transcranial direct current stimulation of the left ventral motor cortex. Exp Brain Res. 2020 Jun;238(6):1525-1535. doi: 10.1007/s00221-020-05832-9. Epub 2020 May 23.

  PMID: 32447409 BACKGROUND

• Peng D, Lin Q, Chang Y, Jones JA, Jia G, Chen X, Liu P, Liu H. A Causal Role of the Cerebellum in Auditory Feedback Control of Vocal Production. Cerebellum. 2021 Aug;20(4):584-595. doi: 10.1007/s12311-021-01230-1. Epub 2021 Feb 8.

  PMID: 33555544 BACKGROUND

• Thair H, Holloway AL, Newport R, Smith AD. Transcranial Direct Current Stimulation (tDCS): A Beginner's Guide for Design and Implementation. Front Neurosci. 2017 Nov 22;11:641. doi: 10.3389/fnins.2017.00641. eCollection 2017.

  PMID: 29213226 BACKGROUND

• Wang B, Xiao S, Yu C, Zhou J, Fu W. Effects of Transcranial Direct Current Stimulation Combined With Physical Training on the Excitability of the Motor Cortex, Physical Performance, and Motor Learning: A Systematic Review. Front Neurosci. 2021 Apr 9;15:648354. doi: 10.3389/fnins.2021.648354. eCollection 2021.

  PMID: 33897361 BACKGROUND

• Perikova E, Blagovechtchenski E, Filippova M, Shcherbakova O, Kirsanov A, Shtyrov Y. Anodal tDCS over Broca's area improves fast mapping and explicit encoding of novel vocabulary. Neuropsychologia. 2022 Apr 15;168:108156. doi: 10.1016/j.neuropsychologia.2022.108156. Epub 2022 Jan 10.

  PMID: 35026217 BACKGROUND

• Cardoso NSV, Lucena JA, de Lira ZS, de Vasconcelos SJ, Lopes LW, Gomes AOC. Do Flexible Silicone Tubes Immersed in Water Combined With Vocalise Improve the Immediate Effect on Voice? J Speech Lang Hear Res. 2021 Dec 13;64(12):4535-4562. doi: 10.1044/2021_JSLHR-20-00629. Epub 2021 Nov 11.

  PMID: 34762812 BACKGROUND

Related Links

• Immediate Effect of a Resonance Tube on the Vocal Range Profile of Choristers

MeSH Terms

Conditions

Voice Disorders; Communication Disorders

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Laryngeal Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurobehavioral Manifestations; Neurodevelopmental Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Officials

• kelly Greyce SC Oliveira, PhD student

  UFPE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical professor

Study Record Dates

• First Submitted: July 9, 2024
• First Posted: August 9, 2024
• Study Start: March 30, 2023
• Primary Completion: December 12, 2023
• Study Completion: April 20, 2024
• Last Updated: August 15, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)