Evaluation of the Effect of Hypericum Perforatum L and Hyaluronic Acid on Excisional Palatal Wound Healing

NCT06543199 | Completed

• 1 other identifier: 421
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The free gingival graft (FGG) procedure is one of the surgical approaches used to create a large area of adherent gingiva around the tooth and implant. As part of this procedure, one SDG at a time is harvested from the donor site of the secondary healing palate. The most common postoperative complications are pain, burning sensation and delayed wound healing at the donor site. Many agents have been used for years to reduce these complications, but so far none has been emphasized as the ideal agent. In this thesis, methods to improve the healing of the hard palate, the donor site for SDG surgery, and postoperative patient comfort will be compared.

Conditions

Wound Healing Disorder; Palate; Wound

Keywords

palatal wound healing; hyaluronic acid; Hypericum perforatum L

Outcome Measures

Primary Outcomes (3)

• assessment of pain at the donor site

  Measuring and recording the pain score at the donor site with a vas

  Days 1,2,3,4,4,5,6,7

• evaluation of burning in the donor area

  Measuring and recording the burning score at the donor site with a vas

  Days 1,2,3,4,4,5,6,7

• evaluation of chewing discomfort at the donor site

  Measuring and recording the chewing discomfort score at the donor site with a vas

  Days 1,2,3,4,4,5,6,7

Study Arms (3)

CONTROL

EXPERIMENTAL

Group in which no agent was used in the area left for secondary healing at the donor site.

Procedure: wound healing monitoring

HYPERICUM PERFORATUM L

EXPERIMENTAL

Group using hypericum perforatum L agent in the area left for secondary healing at the donor site.

Procedure: Local application of hypericum perforatum L to the wound site; Procedure: wound healing monitoring

HYALURONIC ASID

EXPERIMENTAL

Group using hyaluronıc acid agent in the area left for secondary healing at the donor site.

Procedure: local application of hyaluronic acid agent to the wound site; Procedure: wound healing monitoring

Interventions

local application of hyaluronic acid agent to the wound site PROCEDURE

Evaluation of the effect of local use of hyaluronic acid agent on wound healing

HYALURONIC ASID

Local application of hypericum perforatum L to the wound site PROCEDURE

Hyperıcum perforatum L ajanının lokal kullanımının yara iyileşmesine etkisinin değerlendirilmesi

HYPERICUM PERFORATUM L

wound healing monitoring PROCEDURE

Doctor visit on days 3, 7, 14, 21 and 28

CONTROL; HYALURONIC ASID; HYPERICUM PERFORATUM L

Eligibility Criteria

• Age: 18 Years - 60 Years
• Gender Eligibility Details: the fact that wound healing in the oral region is more difficult in women compared to men in this surgery.
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• The patient is in need of free gingival graft (FGG) surgery,
• The patient's acceptance of the treatment,
• All oral plaque and bleeding scores less than 20%.
• Age between 18-60 years.

You may not qualify if:

• The patient does not need SDG surgery,
• The patient is a smoker,
• The patient has a systemic disease that will affect recovery,
• The patient is unable to attend follow-up sessions,
• Previous periodontal surgery,
• The patient is pregnant or lactating,
• The patient has used antibiotics, corticosteroids, anti-inflammatory, immunosuppressive drugs in the last 6 months.
• Tooth deficiency such that the patient cannot wear acrylic aligners
• Acute periodontal condition

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Tuğba Aydın

Erzurum, Hiçbiri Seçilmedi, 25240, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor doctor

Study Record Dates

• First Submitted: August 4, 2024
• First Posted: August 7, 2024
• Study Start: January 2, 2024
• Primary Completion: August 20, 2024
• Study Completion: August 28, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)