Risk Factors for Adverse Outcomes in Sepsis

NCT06541600 | Completed

• 1 other identifier: TJ-IRB20230823
• Study Type: observational
• Target: 10,313
• Locations: 1 country
• Sites: 1

Brief Summary

This study will adopt a retrospective clinical cohort design and include a certain scale of sepsis patients as research objects to find the risk factors for adverse outcomes in patients with sepsis. Bioinformatics techniques were used to infer potential differential genes corresponding to different risk factors. Finally, through the biobank the investigators established in the past, biological samples of patients with sepsis were extracted and protein expression in the samples was detected to comprehensively analyze biological information at multiple levels.

Conditions

Sepsis

Keywords

sepsis; Septic cardiomyopathy; KKS

Outcome Measures

Primary Outcomes (2)

• Survival

  Survival

  28 days

• Cardiac function

  Echocardiography (Ejection Fraction (EF))

  24 hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with sepsis

You may qualify if:

• over 18 years old;
• meet the diagnostic criteria for sepsis;
• Duration of hospitalization: lasting more than 24 hours;
• no important comorbidities, such as heart failure, liver and kidney insufficiency, malignant tumor, etc.
• Antibiotic use: The time to start antibiotic treatment should not exceed 48 hours.

You may not qualify if:

• less than 18 years old;
• Clinical anti-infective therapy: Start long-term anti-infective therapy within 14 days before the expected time point of infection;
• Duration of hospitalization: less than 24 hours;
• The presence of other important complications, such as heart failure, liver and kidney insufficiency, and malignant tumors;
• The presence of other important complications, such as heart failure, liver and kidney insufficiency, and malignant tumors;
• The presence of other infectious diseases, such as tuberculosis, HIV/AIDS, etc.

Sponsors & Collaborators

• Qin Zhang: lead

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

Location

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• QIN Zhang, phd

  Tongji Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 6, 2024
• First Posted: August 7, 2024
• Study Start: January 1, 2003
• Primary Completion: January 1, 2023
• Study Completion: January 1, 2023
• Last Updated: August 7, 2024

Record last verified: 2024-08

Locations

CN (1)