Prescribing Appropriateness of Thrombo-prophylaxis in Intensive Care Unit of Tertiary Hospital

NCT06539156 | Completed

• 1 other identifier: 2887764466
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Hospitalized patients are at high risk of venous thromboembolism (VTE), and the appropriate use of thromboprophylaxis can significantly reduce the incidence of VTE in high-risk patients. We investigated the pattern of VTE prophylaxis administration among elderly medical patients and assessed its appropriateness based on the American College of Chest Physicians (ACCP) recommendations. Methods A cross-sectional single-center study will be conducted between July 2024 and December 2024, including hospitalized (\> 48 h), (≥ 60 years), medical and surgical patients, and excluding patients receiving anticoagulant for other reason, having contraindication to thromboprophylaxis, or had VTE diagnosed within 48 h. The Padua and caprine prediction scores will be used to determine the patients' risk for VTE, and thromboprophylaxis use will be assessed against the ACCP recommendations.

Conditions

DVT

Outcome Measures

Primary Outcomes (2)

• Padua score for medical patients

  Venous thromboembolism Risk assessment (Scores 0-3 are low risk and do not warrant prophylaxis. Scores ≥4 are high risk for VTE and subsequent complications; recommendation for thromboprophylaxis.)

  within 24 hours of ICU admission

• Caprini score for surgical patients

  Venous thromboembolism Risk assessment (Total score of 0-1: Low risk of VTE Total score of ≥3: High/moderate risk of VTE )

  within 24 hours of ICU admission

Secondary Outcomes (3)

• Bleeding risk assessment

  within 24 hours of ICU admission

• Direct Anticoagulant cost

  within 24 hours of ICU admission till ICU discharge(at least 48 hours)

• Adverse drug reaction cost

  within 24 hours of ICU admission till ICU discharge (at least 48 hours)

Study Arms (2)

Medical Patients

Other: DVT prophyllaxis

Surgical Patients

Other: DVT prophyllaxis

Interventions

DVT prophyllaxis OTHER

VTE prophylaxis administration among patients based on the American College of Chest Physicians (ACCP) recommendations

Medical Patients; Surgical Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patient records admitted to the ICU with medical or surgical causes treated with anticoagulants for DVT prophylaxis will be collected Patients already on anticoagulant therapy, had history of previous DVT, had End-stage liver disease, admitted with hemorrhage/bleeding or not prescribed DVT prophylaxis will be excluded.

You may qualify if:

• Patient records
• admitted to the ICU with
• medical or surgical causes
• recieved anticoagulants for DVT prophylaxis

You may not qualify if:

• Patients already on anticoagulant therapy,
• had history of previous DVT,
• had End-stage liver disease,
• admitted with hemorrhage/bleeding
• not prescribed DVT prophylaxis

Sponsors & Collaborators

• Ain Shams University: lead
• Egyptian Chinese University: collaborator
• Teachers Hospital: collaborator

Study Sites (1)

Teachers Hospital

Cairo, Cairo Governorate, 4270020, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Pharmacy Associate Professor

Study Record Dates

• First Submitted: July 29, 2024
• First Posted: August 6, 2024
• Study Start: August 1, 2024
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: December 27, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)