Decompression of Odontogenic Cysts

NCT06536907 | Completed

• 1 other identifier: 70904504/553
• Study Type: observational
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this case-control study is to evaluate the effects of decompression of cystic jaw lesions by means of comparing pre- and post-decompression histologic findings. The main question it aims to answer is: Does decompression of cystic jaw lesions alter the histologic diagnosis? A retrospective analysis was performed based on the comparison of initial and final histologic diagnoses of patients with an odontogenic cystic lesion, that was surgically treated with decompression followed by a definitive surgery.

Conditions

Odontogenic Cysts; Keratocysts of the Jaw; Cysts Dental; Pathology

Keywords

biopsy; diagnosis; keratocysts; odontogenic cysts; oral pathology; surgical decompression

Outcome Measures

Primary Outcomes (1)

• Change in histologic diagnosis following decompression (yes/no)

  A comparison will be made between the initial histologic diagnosis and post-decompression definitive histologic diagnosis of the cystic jaw lesions

  A decompression period ranging between 2 and 15 months

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study included patients with a histologic diagnosis of an odontogenic cystic lesion, that was surgically treated with decompression followed by a definitive surgery.

You may qualify if:

• To have an initial diagnosis of an odontogenic cystic jaw lesion confirmed with an incisional biopsy.
• The patients must have undergone decompression and, enucleation or enucleation and peripheral ostectomy after decompression period.

You may not qualify if:

• Previously treated patients
• The patients with missing information in medical and/or dental records
• The patients who did not adhere to follow-up protocol

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

Akdeniz University

Antalya, 07070, Turkey (Türkiye)

Location

Related Publications (18)

• Rajendra Santosh AB. Odontogenic Cysts. Dent Clin North Am. 2020 Jan;64(1):105-119. doi: 10.1016/j.cden.2019.08.002. Epub 2019 Oct 18.

  PMID: 31735221 RESULT

• Wakolbinger R, Beck-Mannagetta J. Long-term results after treatment of extensive odontogenic cysts of the jaws: a review. Clin Oral Investig. 2016 Jan;20(1):15-22. doi: 10.1007/s00784-015-1552-y. Epub 2015 Aug 8.

  PMID: 26250795 RESULT

• Oliveros-Lopez L, Fernandez-Olavarria A, Torres-Lagares D, Serrera-Figallo MA, Castillo-Oyague R, Segura-Egea JJ, Gutierrez-Perez JL. Reduction rate by decompression as a treatment of odontogenic cysts. Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e643-e650. doi: 10.4317/medoral.21916.

  PMID: 28809378 RESULT

• Mohanty S, Dabas J, Verma A, Gupta S, Urs AB, Hemavathy S. Surgical management of the odontogenic keratocyst: A 20-year experience. Int J Oral Maxillofac Surg. 2021 Sep;50(9):1168-1176. doi: 10.1016/j.ijom.2021.02.015. Epub 2021 Mar 2.

  PMID: 33663899 RESULT

• Anavi Y, Gal G, Miron H, Calderon S, Allon DM. Decompression of odontogenic cystic lesions: clinical long-term study of 73 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):164-9. doi: 10.1016/j.tripleo.2010.09.069. Epub 2010 Dec 30.

  PMID: 21194990 RESULT

• Pogrel MA, Jordan RC. Marsupialization as a definitive treatment for the odontogenic keratocyst. J Oral Maxillofac Surg. 2004 Jun;62(6):651-5; discussion 655-6. doi: 10.1016/j.joms.2003.08.029.

  PMID: 15170272 RESULT

• Schlieve T, Miloro M, Kolokythas A. Does decompression of odontogenic cysts and cystlike lesions change the histologic diagnosis? J Oral Maxillofac Surg. 2014 Jun;72(6):1094-105. doi: 10.1016/j.joms.2013.12.028. Epub 2014 Jan 15.

  PMID: 24576437 RESULT

• Allon DM, Allon I, Anavi Y, Kaplan I, Chaushu G. Decompression as a treatment of odontogenic cystic lesions in children. J Oral Maxillofac Surg. 2015 Apr;73(4):649-54. doi: 10.1016/j.joms.2014.10.024. Epub 2014 Oct 31.

  PMID: 25631867 RESULT

• Berretta LM, Melo G, Mello FW, Lizio G, Rivero ERC. Effectiveness of marsupialisation and decompression on the reduction of cystic jaw lesions: a systematic review. Br J Oral Maxillofac Surg. 2021 Dec;59(10):E17-E42. doi: 10.1016/j.bjoms.2021.03.004. Epub 2021 Mar 23.

  PMID: 34749963 RESULT

• August M, Faquin WC, Troulis MJ, Kaban LB. Dedifferentiation of odontogenic keratocyst epithelium after cyst decompression. J Oral Maxillofac Surg. 2003 Jun;61(6):678-83; discussion 683-4. doi: 10.1053/joms.2003.50137.

  PMID: 12796876 RESULT

• Nakamura N, Mitsuyasu T, Mitsuyasu Y, Taketomi T, Higuchi Y, Ohishi M. Marsupialization for odontogenic keratocysts: long-term follow-up analysis of the effects and changes in growth characteristics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Nov;94(5):543-53. doi: 10.1067/moe.2002.128022.

  PMID: 12424446 RESULT

• von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Bull World Health Organ. 2007 Nov;85(11):867-72. doi: 10.2471/blt.07.045120.

  PMID: 18038077 RESULT

• Castro-Nunez J. Decompression of Odontogenic Cystic Lesions: Past, Present, and Future. J Oral Maxillofac Surg. 2016 Jan;74(1):104.e1-9. doi: 10.1016/j.joms.2015.09.004. Epub 2015 Sep 21.

  PMID: 26428611 RESULT

• Mustansir-Ul-Hassnain S, Chandavarkar V, Mishra MN, Patil PM, Bhargava D, Sharma R. Histopathologic and immunohistochemical findings of odontogenic jaw cysts treated by decompression technique. J Oral Maxillofac Pathol. 2021 May-Aug;25(2):272-278. doi: 10.4103/0973-029X.325126. Epub 2021 Aug 31.

  PMID: 34703121 RESULT

• Castro-Nunez J, Wiscovitch AG, Porte JP, Wiscovitch J, Rivera B, Guerrero LM. Does active decompression of odontogenic keratocyst change the histologic diagnosis? Oral Maxillofac Surg. 2022 Jun;26(2):291-298. doi: 10.1007/s10006-021-00994-4. Epub 2021 Jul 29.

  PMID: 34324108 RESULT

• Awni S, Conn B. Decompression of keratocystic odontogenic tumors leading to increased fibrosis, but without any change in epithelial proliferation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jun;123(6):634-644. doi: 10.1016/j.oooo.2016.12.007. Epub 2016 Dec 30.

  PMID: 28377093 RESULT

• Rodu B, Tate AL, Martinez MG Jr. The implications of inflammation in odontogenic keratocysts. J Oral Pathol. 1987 Nov;16(10):518-21. doi: 10.1111/j.1600-0714.1987.tb00684.x.

  PMID: 3127567 RESULT

• Zhang L, Liu SL, Ye WM, Zheng J. STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst. Am J Transl Res. 2015 Oct 15;7(10):1860-9. eCollection 2015.

  PMID: 26692930 RESULT

MeSH Terms

Conditions

Odontogenic Cysts; Radicular Cyst; Disease

Condition Hierarchy (Ancestors)

Jaw Cysts; Bone Cysts; Cysts; Neoplasms; Jaw Diseases; Musculoskeletal Diseases; Stomatognathic Diseases; Periodontal Cyst; Periapical Diseases; Periodontal Diseases; Mouth Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: July 31, 2024
• First Posted: August 5, 2024
• Study Start: January 1, 2015
• Primary Completion: December 31, 2018
• Study Completion: September 1, 2023
• Last Updated: August 5, 2024

Record last verified: 2024-07

Locations

TU (1)