Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

NCT06536452 | Recruiting

• 1 other identifier: 16-006204
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.

Conditions

Monoclonal B-Cell Lymphocytosis; Chronic Lymphocytic Leukemia

Outcome Measures

Primary Outcomes (2)

• Effects of MBL on bone marrow function

  Samples collected from healthy participants and participants with MBL will be compared for differences in bone marrow function (i.e., ability to fight off infection). Results will be descriptive. With participant permission, samples will be stored for future research use.

  Baseline

• Effects of CLL on bone marrow function

  Samples collected from healthy participants and participants with CLL will be compared for differences in bone marrow function (i.e., ability to fight off infection). Results will be descriptive. With participant permission, samples will be stored for future research use.

  Baseline

Study Arms (1)

Observational

Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study.

Other: Non-Interventional Study

Interventions

Non-Interventional Study OTHER

Non-interventional study

Observational

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with MBL, patients with CLL ,and healthy subjects recruited through Mayo Clinic.

You may qualify if:

• Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who
• Remain untreated
• Are currently being treated
• Who have already been treated
• Subjects in the MBL cohort will have a clinically established diagnosis of MBL
• Healthy age-matched control subjects
• Healthy younger control subjects aged \> 40 years

You may not qualify if:

• Anyone under 40
• Healthy control subjects must not have a diagnosis of CLL or MBL

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

RECRUITING

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Conditions

Leukemia, Lymphocytic, Chronic, B-Cell

Condition Hierarchy (Ancestors)

Leukemia, B-Cell; Leukemia, Lymphoid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Neil E. Kay, M.D.

  Mayo Clinic in Rochester

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 31, 2024
• First Posted: August 5, 2024
• Study Start: November 18, 2016
• Primary Completion (Estimated): November 18, 2028
• Study Completion (Estimated): November 18, 2028
• Last Updated: March 31, 2026

Record last verified: 2026-03

Locations

US (1)