Clinical Characteristics and Outcomes Among STEMI Patients With Cardiogenic Shock at Abu Dhabi City

NCT06535503 | Recruiting

• 1 other identifier: SEHAResearch ID 747
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 2

Brief Summary

A retrospective study on the clinical characteristics and treatment outcomes of patients admitted with ST-elevation Myocardial Infarction (STEMI) complicated with cardiogenic shock (CS) during admission or CS development during their hospital stay for two tertiary hospitals in Abu Dhabi, UAE, from 2020-2024.

Conditions

ST Elevation Myocardial Infarction; Cardiogenic Shock

Keywords

STEMI; Cardiogenic Shock; Morbidity; Mortality

Outcome Measures

Primary Outcomes (5)

• Analyze STEMI patient with CS disease profile

  Comorbidities, demographical information, past medical history, morbidity

  5 years

• Incidence of CS-complicated AMI events

  The incidence of CS-complicated AMI events will show an increase over the years because of advanced diagnostic modalities and a clearer definition of CS.

  5 years

• Analyze treatment outcomes in the targeted population as per the patient profile

  Incidence of Mortality

  5 years

• Analyze STEMI patient with CS disease profile

  Incidence of Morbidity

  5 years

• Analyze treatment outcomes

  % of patients who were discharged

  5 years

Study Arms (1)

Patients with STEMI & Cardiogenic Shock

Patients with STEMI complicated by cardiogenic shock on admission or after hospitalization treated at SKMC \& SSMC, Abu Dhbai

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with STEMI complicated by cardiogenic shock on admission or after hospitalization were treated in Abu Dhabi city from January 2020 to January 2024.

You may qualify if:

• Age more than 18.
• STEMI complicated by cardiogenic shock.
• Were hospitalized or treated at SSMC or SKMC for STEMI complicated by cardiogenic shock.
• Patient admitted between January 2019 to March 2024.

You may not qualify if:

• Age less than 18.
• Shock patient not related to Myocardial infarction.
• NSTEMI-related cardiogenic shock.
• Patients who were not treated at SSMC or SKMC for the STEMI complicated by cardiogenic shock.
• Patient not admitted between January 2019 to March 2024.

Sponsors & Collaborators

• Abu Dhabi Health Services Company: lead
• Sheikh Shakhbout Medical City: collaborator
• Sheikh Khalifa Medical City: collaborator

Study Sites (2)

Sheikh Khalifa Medical City (SKMC)

Abu Dhabi, Abu Dhabi Emirate, 11001, United Arab Emirates

RECRUITING

Sheikh Shakhbout Medical City (SKMC)

Abu Dhabi, Abu Dhabi Emirate, 11001, United Arab Emirates

RECRUITING

Related Publications (6)

• Al-Shamsi S, Regmi D, Govender RD. Incidence of cardiovascular disease and its associated risk factors in at-risk men and women in the United Arab Emirates: a 9-year retrospective cohort study. BMC Cardiovasc Disord. 2019 Jun 17;19(1):148. doi: 10.1186/s12872-019-1131-2.

  PMID: 31208354 BACKGROUND

• Akbar H, Mountfort S. Acute ST-Segment Elevation Myocardial Infarction (STEMI). 2024 Oct 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK532281/

  PMID: 30335314 BACKGROUND

• De Luca L, Olivari Z, Farina A, Gonzini L, Lucci D, Di Chiara A, Casella G, Chiarella F, Boccanelli A, Di Pasquale G, De Servi S, Bovenzi FM, Gulizia MM, Savonitto S. Temporal trends in the epidemiology, management, and outcome of patients with cardiogenic shock complicating acute coronary syndromes. Eur J Heart Fail. 2015 Nov;17(11):1124-32. doi: 10.1002/ejhf.339. Epub 2015 Sep 4.

  PMID: 26339723 BACKGROUND

• Holmes DR Jr, Bates ER, Kleiman NS, Sadowski Z, Horgan JH, Morris DC, Califf RM, Berger PB, Topol EJ. Contemporary reperfusion therapy for cardiogenic shock: the GUSTO-I trial experience. The GUSTO-I Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries. J Am Coll Cardiol. 1995 Sep;26(3):668-74. doi: 10.1016/0735-1097(95)00215-p.

  PMID: 7642857 BACKGROUND

• Shalaby G, Niazi AK, Khaled S. Cardiogenic Shock Among Patients with Acute ST-Segment Elevation Myocardial Infarction in a Middle Eastern Country: A Single-Center Experience. J Saudi Heart Assoc. 2023 Jan 20;34(4):232-240. doi: 10.37616/2212-5043.1323. eCollection 2022.

  PMID: 36816794 BACKGROUND

• Yusufali A, Bazargani N, Muhammed K, Gabroun A, AlMazrooei A, Agrawal A, Al-Mulla A, Hajat C, Baslaib F, Philip J, Gupta P, Bakir S, Krishnan S, Almahmeed W, Alsheikh-Ali A. Opportunistic Screening for CVD Risk Factors: The Dubai Shopping for Cardiovascular Risk Study (DISCOVERY). Glob Heart. 2015 Dec;10(4):265-72. doi: 10.1016/j.gheart.2015.04.008. Epub 2015 Aug 11.

  PMID: 26271552 BACKGROUND

Related Links

• Kosaraju, A., Pendela, V. S., \& Hai, O. (2023, April 7). Cardiogenic shock. StatPearls \[Internet\]. https://www.ncbi.nlm.nih.gov/books/NBK482255/
• High prevalence of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study.

MeSH Terms

Conditions

ST Elevation Myocardial Infarction; Shock, Cardiogenic

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Shock

Study Officials

• Abdulmajeed BS Alzubaidi, MD

  Abu Dhabi Health Services Co. -SEHA

  STUDY CHAIR

• Babiker Babiker Mohamed Babiker Elsiraj MB Elsiraj

  Sheikh Shakhbout Medical City

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Alina Naeem, MBBS

CONTACT

0097124102534; alnaeem@seha.ae

Babiker Babiker Mohamed Babiker Elsiraj MB Elsiraj, MD

CONTACT

0564972830; Belsiraj@seha.ae

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Cardiology Specialist/Fellow at Sheikh Shakhbout Medical City

Study Record Dates

• First Submitted: May 13, 2024
• First Posted: August 2, 2024
• Study Start: July 1, 2024
• Primary Completion: January 1, 2025
• Study Completion: May 30, 2025
• Last Updated: February 17, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: CSR
• Time Frame: The data will be available for 5 years after the analysis is completed
• Access Criteria: REDCap or PI \& Facility Permission

Locations

AE (2)