Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia

NCT06534658 | Recruiting DMC

• 1 other identifier: BP-MIMI
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 8

Brief Summary

This project is a multicenter observational study that establishes a longitudinal cohort of patients with Alzheimer's disease and other dementias based on neuroimaging, molecular imaging, biological and digital markers to explore new solutions such as dementia disease mechanism, diagnosis, condition evaluation, and prognosis assessment.

Conditions

Alzheimer Disease; Image

Keywords

Alzheimer Disease; molecular imaging

Outcome Measures

Primary Outcomes (1)

• The change of incidence of cognitive impairment

  Number of participants who covert to AD or mild cognitive impairment (MCI) will be recorded to calculate the incidence.

  baseline, 1 year, 2 year, 3 year, 4 year

Secondary Outcomes (13)

• The change of Mini-Mental State Examination (MMSE)

  baseline, 1 year, 2 year, 3 year, 4 year

• The change of Montreal cognitive assessment-Basic (MoCA)

  baseline, 1 year, 2 year, 3 year, 4 year

• The change of Auditory verbal learning test (AVLT)

  baseline, 1 year, 2 year, 3 year, 4 year

• The change of structural MRI

  baseline, 1 year, 2 year, 3 year, 4 year

• The change of functional MRI

  baseline, 1 year, 2 year, 3 year, 4 year

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The population in this study includes the cognitive impairment patients in Ruijin Hospital, Renji Hospital, The First Hospital of Zhejiang University School of Medicine, The First Hospital of China Medical University.

You may qualify if:

• Patients aged ≥50 and ≤85 years old, male or female;
• Meet the diagnostic criteria for dementia or MCI;
• Neuropsychological score: MMSE 15-28 points, CDR ≤ 1 point; ④ Patients and their families are informed and sign the informed consent form

You may not qualify if:

• The presence of other neurological diseases that may cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.);
• The presence of other systemic diseases that may cause cognitive impairment (such as liver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
• Suffering from a disease that makes it impossible to cooperate with cognitive examinations;
• The presence of contraindications to MRI;
• The presence of mental and neurological retardation;
• Refusing to draw blood;
• Refusing to sign the informed consent form.

Sponsors & Collaborators

• Ruijin Hospital: lead

Study Sites (8)

Chinese People's Liberation Army General Hospital

Beijing, Beijing Municipality, China

RECRUITING

First Affiliated Hospital of Zhejiang University School of Medicine

Hanzhong, Hangzhou, China

RECRUITING

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine

Cangzhou, Hebei, China

RECRUITING

The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

RECRUITING

Qilu Hospital of Shandong University, Qingdao Branch

Qingdao, Shandong, China

RECRUITING

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200025, China

RECRUITING

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200025, China

RECRUITING

The First Affiliated Hospital of China Medical University

Shenyang, Shenyang, China

RECRUITING

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Gang Wang, PhD. MD.

  RenJi Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jintao Wang

CONTACT

18221457023; jt_wang@sjtu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2024
• First Posted: August 2, 2024
• Study Start: July 30, 2020
• Primary Completion (Estimated): July 30, 2029
• Study Completion (Estimated): August 30, 2029
• Last Updated: August 2, 2024

Record last verified: 2024-07

Locations

CN (8)