Ultrasound of the Inferior Vena Cava in the Prevention of Hypotension After Induction of General Anesthesia

NCT06530901 | Not Yet Recruiting

• 1 other identifier: 20240725
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Based on the preoperative ultrasound detection of various parametric indicators of the inferior vena cava cross-section, including the ratio of the inferior vena cava's long and short axes, cross-sectional area and circumference during two-dimensional and three-dimensional imaging, as well as the changes in respiratory variability of each parameter, we explored the predictive value of IVC ultrasound indicator parameters on hypotension after induction of general anesthesia in elderly patients undergoing elective non-cardiac surgery, screened the sensitive indicators, and calculated the cut-off values.

Conditions

Elderly Patients Undergoing Elective Non-cardiac Surgery

Keywords

hypotension; general anesthesia; inferior vena cava

Outcome Measures

Primary Outcomes (3)

• Changes in the level of Mean Arterial Pressure

  The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction

  Baseline (before induction), 10 min after induction

• Changes in the level of Systolic Blood Pressure

  The outcome above should be measured at the time before induction, 1 min after induction, 2 min after induction, 3 min after induction, 4 min after induction, 5 min after induction,10 min after induction

  Baseline (before induction), 10 min after induction

• Multidimensional ultrasound of the inferior vena cava

  The outcome above should be measured at the time before induction

  Baseline (before induction)

Secondary Outcomes (2)

• Changes in the level of Heart Rate

  Baseline (before induction), 10 min after induction

• Changes in the level of Diastolic Blood Pressure

  Baseline (before induction), 10 min after induction

Study Arms (1)

Elderly patients undergoing elective noncardiac surgery under general anesthesia

Diagnostic Test: Multidimensional ultrasound of the inferior vena cava

Interventions

Multidimensional ultrasound of the inferior vena cava DIAGNOSTIC_TEST

Cross-sectional parameters of the inferior vena cava include two-dimensional longitudinal diameter, cross-sectional length and short diameter, circumference, and cross-sectional area, as well as cross-sectional length and short diameter, circumference, and cross-sectional area in three-dimensional imaging

Elderly patients undergoing elective noncardiac surgery under general anesthesia

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly patients undergoing elective non-cardiac surgery under general anesthesia

You may qualify if:

• Elderly patients undergoing elective non-cardiac surgery under general anesthesia;
• Age 65-85 years old;
• Body mass index (BMI) 18-28 kg/m2;
• American society of anesthesiologists (ASA) class I-III.

You may not qualify if:

• Patient refusal or lack of cooperation;
• Inability to communicate properly;
• Severe sinus bradycardia, pacemaker implantation, atrioventricular block, and atrial fibrillation;
• Presence of severe hepatic and renal function abnormalities;
• Preoperative cardiac ultrasound suggesting LVEF \<50%;
• Tricuspid valve displacement \<16 mm by preoperative cardiac ultrasound;
• Chronic obstructive pulmonary disease;
• Pulmonary hypertension;
• Administration of drugs that inhibit the renin-angiotensin-aldosterone system;
• Possibility of a difficult airway.

Sponsors & Collaborators

• Zhuan Zhang: lead

Study Sites (1)

the Affiliated Hospital of Yangzhou University, Yangzhou University

Yangzhou, Jiangsu, China

Location

MeSH Terms

Conditions

Hypotension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• zhuan zhang, professor

  The Affiliated Hospital of Yangzhou University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

zhuan zhang, professor

CONTACT

+8615062791355; zhangzhuancg@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: July 28, 2024
• First Posted: July 31, 2024
• Study Start: September 1, 2024
• Primary Completion: March 31, 2025
• Study Completion: March 31, 2025
• Last Updated: August 5, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)