Cardiovascular Response to Isometric BFR Exercise

NCT06529068 | Completed

• 1 other identifier: STUDY00006378
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is: The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff). Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.

Conditions

Blood Pressure

Outcome Measures

Primary Outcomes (3)

• Systolic blood pressure and diastolic blood pressure

  Beat-by-beat (both systolic and diastolic blood pressure) blood pressure before, during, and after exercise

  20 minutes

• Brachial artery diameter evaluated by an ultrasound machine

  Brachial artery diameter will be measured by an ultrasound machine to calculate flow-mediated dilation (FMD)

  Before and 20 minutes after exercise

• Heart rate

  Monitor heart rate continuously before, during, and after exercise

  20 minutes

Study Arms (3)

Isometric exercise without BFR cuff (control)

ACTIVE COMPARATOR

Behavioral: Isometric handgrip exercise

Isometric exercise with narrow-elastic BFR band

EXPERIMENTAL

Behavioral: Isometric handgrip exercise with a narrow-elastic band

Isometric exercise with wide-rigid BFR cuff

EXPERIMENTAL

Behavioral: Isometric handgrip exercise with a wide-rigid cuff

Interventions

Isometric handgrip exercise BEHAVIORAL

The participants will perform isometric handgrip exercises without blood flow restriction.

Isometric exercise without BFR cuff (control)

Isometric handgrip exercise with a narrow-elastic band BEHAVIORAL

The participants will perform isometric handgrip exercises with blood flow restriction using a narrow-elastic band.

Isometric exercise with narrow-elastic BFR band

Isometric handgrip exercise with a wide-rigid cuff BEHAVIORAL

The participants will perform isometric handgrip exercises with blood flow restriction using a wide-rigid cuff.

Isometric exercise with wide-rigid BFR cuff

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.

You may not qualify if:

• Abnormal clotting times
• Acid-base imbalance/acidosis
• Arterial calcification
• Atherosclerotic vessels
• Cardiopulmonary conditions
• Diabetes
• Dialysis/central venous access
• General/local infection
• High intracranial pressure
• Hip, pelvis, or femur fracture
• History of venous thromboembolism
• Hypertension
• Immobility for greater than 48 hours in the past month
• Immobilizing cast
• Implanted medical device

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

Cardiovascular Aging Research Laboratory

Austin, Texas, 78712-1415, United States

Location

Related Publications (9)

• Lind AR. Cardiovascular responses to static exercise. (Isometrics, anyone?). Circulation. 1970 Feb;41(2):173-6. doi: 10.1161/01.cir.41.2.173. No abstract available.

  PMID: 5412979 BACKGROUND

• Domingos E, Polito MD. Blood pressure response between resistance exercise with and without blood flow restriction: A systematic review and meta-analysis. Life Sci. 2018 Sep 15;209:122-131. doi: 10.1016/j.lfs.2018.08.006. Epub 2018 Aug 4.

  PMID: 30086274 BACKGROUND

• Bond CW, Hackney KJ, Brown SL, Noonan BC. Blood Flow Restriction Resistance Exercise as a Rehabilitation Modality Following Orthopaedic Surgery: A Review of Venous Thromboembolism Risk. J Orthop Sports Phys Ther. 2019 Jan;49(1):17-27. doi: 10.2519/jospt.2019.8375. Epub 2018 Sep 12.

  PMID: 30208794 BACKGROUND

• Mannozzi J, Al-Hassan MH, Kaur J, Lessanework B, Alvarez A, Massoud L, Aoun K, Spranger M, O'Leary DS. Blood flow restriction training activates the muscle metaboreflex during low-intensity sustained exercise. J Appl Physiol (1985). 2023 Aug 1;135(2):260-270. doi: 10.1152/japplphysiol.00274.2023. Epub 2023 Jun 22.

  PMID: 37348015 BACKGROUND

• Song JS, Yamada Y, Wong V, Bell ZW, Spitz RW, Abe T, Loenneke JP. Hypoalgesia following isometric handgrip exercise with and without blood flow restriction is not mediated by discomfort nor changes in systolic blood pressure. J Sports Sci. 2022 Mar;40(5):518-526. doi: 10.1080/02640414.2021.2003569. Epub 2021 Nov 25.

  PMID: 34823439 BACKGROUND

• Renzi CP, Tanaka H, Sugawara J. Effects of leg blood flow restriction during walking on cardiovascular function. Med Sci Sports Exerc. 2010 Apr;42(4):726-32. doi: 10.1249/MSS.0b013e3181bdb454.

  PMID: 19952840 BACKGROUND

• Early KS, Rockhill M, Bryan A, Tyo B, Buuck D, McGinty J. EFFECT OF BLOOD FLOW RESTRICTION TRAINING ON MUSCULAR PERFORMANCE, PAIN AND VASCULAR FUNCTION. Int J Sports Phys Ther. 2020 Dec;15(6):892-900. doi: 10.26603/ijspt20200892.

  PMID: 33344005 BACKGROUND

• Credeur DP, Hollis BC, Welsch MA. Effects of handgrip training with venous restriction on brachial artery vasodilation. Med Sci Sports Exerc. 2010 Jul;42(7):1296-302. doi: 10.1249/MSS.0b013e3181ca7b06.

  PMID: 20019641 BACKGROUND

• Schneider AC, Hughes WE, Ueda K, Bock JM, Casey DP. Reduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation. Nitric Oxide. 2018 Aug 1;78:81-88. doi: 10.1016/j.niox.2018.05.010. Epub 2018 Jun 1.

  PMID: 29864505 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2024
• First Posted: July 31, 2024
• Study Start: December 2, 2024
• Primary Completion: May 30, 2025
• Study Completion: May 30, 2025
• Last Updated: June 12, 2025

Record last verified: 2025-06

Locations

US (1)