NCT06525415

Brief Summary

We investigate the peri-operative foot perfusion through dynamic contrast enhanced MRI in patients with peripheral artery disease

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Aug 2024

Shorter than P25 for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 24, 2024

Completed
5 days until next milestone

First Posted

Study publicly available on registry

July 29, 2024

Completed
3 days until next milestone

Study Start

First participant enrolled

August 1, 2024

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 31, 2024

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2024

Completed
Last Updated

July 29, 2024

Status Verified

July 1, 2024

Enrollment Period

3 months

First QC Date

July 24, 2024

Last Update Submit

July 24, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • preoperative perfusion parameters

    preoperative perfusion parameters by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)

    Between Aug.1 2024 and OCT.31 2024

Secondary Outcomes (3)

  • ankle brachial index

    Between Aug.1 2024 and OCT.31 2024

  • clinical success

    Between Aug.1 2024 and NOV.30 2024

  • survival

    Between Aug.1 2024 and NOV.30 2024

Study Arms (1)

PAD group

patients of peripheral artery disease who underwent endovascular treatment

Diagnostic Test: DCE MRI

Interventions

DCE MRIDIAGNOSTIC_TEST

the recruited patients should complete pre- and post-operative DCE MRI workshops

PAD group

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

patients with peripheral artery disease, who had a successful endovascular treatment and completed both pre- and post-operative MRI workups

You may qualify if:

  • to 80 years old;
  • PAD patients with Fontaine grade II-IV or Rutherford grade 2-6 and underwent a successful revascularization;
  • Patients completed both pre- and post-operative MRI workups;
  • Patients signed the informed consent form and be able to complete the clinical follow-up for 1 months.

You may not qualify if:

  • Patients has participated in other clinical studies;
  • Patients with Heart failure (NYHA III/IV)/right to left shunt heart disease/ severe aortic and mitral insufficiency/acute coronary syndrome/malignant arrhythmia/severe pulmonary hypertension (pulmonary artery pressure at least 90 mmHg)/moderate to severe renal insufficiency (creatinine clearance rate\<60 ml/min)
  • Any allergic constitution;
  • Pregnancy and childbirth;
  • Life expectancy\<12 months.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Peripheral Arterial Disease

Interventions

Dynamic Contrast Enhanced Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

AtherosclerosisArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesPeripheral Vascular Diseases

Intervention Hierarchy (Ancestors)

Magnetic Resonance ImagingTomographyDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosis

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director

Study Record Dates

First Submitted

July 24, 2024

First Posted

July 29, 2024

Study Start

August 1, 2024

Primary Completion

October 31, 2024

Study Completion

November 30, 2024

Last Updated

July 29, 2024

Record last verified: 2024-07