Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment

NCT06522438 | Recruiting

• 1 other identifier: 346806
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 2

Brief Summary

This parallel-group, pilot study will test the hypothesis that the adjunctive use of a thermosensitive gel containing Hyaluronic Acid (HA) and Octenidine to non-surgical periodontal treatment (NSPT) will be able to modulate the early wound healing events. This will be assessed through the expression of specific gingival crevicular fluid markers, as well as by changes in gingival blood flow (assessed by laser speckle contrast imaging), bacterial load, soft tissues contour, clinical parameters and patient-reported outcomes. The study will involve up to 26 patients and will take place at the Centre for Oral Clinical Research (COCR), at the Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London under The Royal London Dental Hospital, Barts Health NHS Trust. Patients will be randomised to receive either NSPT alone or NSPT+ HA and Octenidine gel, and will be followed up to 3 months after treatment. The study will consist of 7- 8 visits.

Conditions

Wound Heal; Periodontal Pocket; Periodontal Inflammation; Periodontal Attachment Loss; Periodontitis

Keywords

Hyaluronic Acid; Octenidine; Biomarkers; Non-surgical periodontal treatment

Outcome Measures

Primary Outcomes (1)

• Changes in the expression of GCF wound healing biomarkers

  Changes in the expression of GCF wound healing biomarkers at 1, 7, 15, 30 days and 3 months following treatment will be assessed. A subset of analytes involved in the healing process and signalling pathways such as i) inflammation/immune response (e.g., IL-1 β, IL-1 α, IL-6, IL-8, IL-4, IL-10,IL-17, TNF- α, MMP-1, MMP-8, MMP-9, TIMP-1), ii) bone formation/resorption (e.g., TGF- β, osteocalcin, osteopontin, osteoprotegerin, BMP-2), iii) oxidative stress (e.g., Myeloperoxidase), and iv) angiogenesis (e.g., VEGF, angiopoietin-1) will be selected based on the pathways identified and optimized in the genomic and proteomic work from our group. Multiplex immunoassays will be designed specifically for quantitative analyses in the GCF for the 2 groups at the different time points.

  Baseline, 1, 7, 15, 30 days and 3 months following treatment

Secondary Outcomes (13)

• Changes in the Blood flow

  Baseline and at 1, 7, 15, and 30 days following treatment.

• Changes in the bacterial load

  Baseline and at 7, 15, 30 days and 3 months following treatment.

• Changes in the probing pocket depth (PPD)

  Baseline and at 3 months after intervention

• Changes in the gingival recession (REC)

  Baseline and at 3 months after intervention

• Changes in the clinical attachment level (CAL)

  Baseline and at 3 months after intervention

Study Arms (2)

Test Group

EXPERIMENTAL

Non-surgical periodontal treatment (NSPT) plus Hyaluronic Acid (HA) and Octenidine gel.

Combination Product: Hyaluronic Acid (HA) and Octenidine gel; Procedure: Non-surgical periodontal treatment (NSPT)

Control Group

ACTIVE COMPARATOR

Non-surgical periodontal treatment (NSPT) alone.

Procedure: Non-surgical periodontal treatment (NSPT)

Interventions

Non-surgical periodontal treatment (NSPT) PROCEDURE

Full mouth supragingival professional mechanical plaque removal (PMPR) and subgingival PMPR at sites with PPD ≥4mm will be performed with the aid of manual and power-driven instruments under local anaesthesia.

Control Group; Test Group

Hyaluronic Acid (HA) and Octenidine gel COMBINATION_PRODUCT

A thermosensitive gel with Hyaluronic Acid (HA) and Octenidine (Pocket-X®, Geistlich, Wolhusen, Switzerland) will be applied in the periodontal pockets ≥5mm immediately after the subgingival PMPR, by means of a pre-filled syringe bearing a thin plastic tip and following manufacturer's instructions.

Test Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or female aged 18 and above
• Engaged patients presenting with a Full Mouth Plaque Score (FMPS) of ≤ 20% within the 6 weeks prior to enrolment, or exhibiting a ≥ 50% reduction in plaque score from the initial screening visit.
• Periodontitis stage III/IV (grades A to C) with at least one site per quadrant with PPD ≥5mm, bleeding on probing and attachment loss ≥5mm
• Willing to sign informed consent and comply with study procedures

You may not qualify if:

• Know hypersensitivity and/or allergy to any of the product's component (as per user leaflet)
• Self-reported pregnancy or lactation
• Smoking (current or in past 5 years), including e-cigarettes/vaping
• Medical history including diabetes mellitus or other serious medical/ psychiatric conditions or transmittable diseases that according to the investigator may increase the risk associated with study participation
• History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures or/and systemic antibiotic therapy during the 3 months preceding the baseline evaluation
• In chronic treatment with anti-inflammatory (including corticosteroids), anticoagulants/antiplatelets (including aspirin), immunosuppressants or other medication that can severely impact wound healing
• History of alcohol or drug abuse
• Subgingival professional mechanical plaque removal (excluding not-extensive subgingival debridement as judged by the examining clinician) and/or surgical periodontal treatment within the last 12 months
• Other severe acute or chronic medical or psychiatric condition or psychological disorder, including limited mental capacity or language skills such that study information could not be understood, informed consent could not be obtained, or simple instructions could not be followed, or any additional conditions which, in the judgement of the investigator, would make the subject inappropriate for entry into this trial

Sponsors & Collaborators

• Queen Mary University of London: lead

Study Sites (2)

Centre for Oral Clinical Research (COCR)

London, E1 2AD, United Kingdom

RECRUITING

The Royal London Dental Hospital, Barts Health NHS Trust

London, E1 2AD, United Kingdom

RECRUITING

MeSH Terms

Conditions

Periodontitis; Periodontal Pocket; Periodontal Attachment Loss

Interventions

Hyaluronic Acid

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy

Intervention Hierarchy (Ancestors)

Glycosaminoglycans; Polysaccharides; Carbohydrates

Study Officials

• Jeniffer Perussolo, DDS, MS, PhD

  QMUL

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Miljana Bacevic, DDS, PhD

CONTACT

+44 02078823063; BHNT.Clinicaloralresearchcentre@nhs.net

Jeniffer Perussolo, DDS, MS, PhD

CONTACT

02078828641; j.perussolo@qmul.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2024
• First Posted: July 26, 2024
• Study Start: June 3, 2025
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: February 5, 2026

Record last verified: 2026-02

Locations

GB (2)