The Role of Short Course of Palliative Radiation in Metastatic Cancer Rectum

NCT06521827 | Not Yet Recruiting

• 1 other identifier: SCRTH in rectal cancer
• Study Type: interventional
• Target: 49
• Locations: 0 countries
• Sites: N/A

Brief Summary

Short-course radiotherapy (SCRT), which allows the delivery of 25 Gy in five daily fractions, has emerged as an attractive strategy for rectal cancer treatment. Surgery can safely be deferred after SCRT, allowing an opportunity to deliver chemotherapy (ChT) preoperatively rather than postoperatively. In cases of metastatic disease, this represents an effective treatment option to improve local control and avoid colostomy in a subset of patients.

Conditions

Metastatic Cancer Rectum

Outcome Measures

Primary Outcomes (1)

• The role of short course of palliative radiation in metastatic cancer rectum.

  The role of short course of palliative radiation in metastatic cancer rectum.

  one year

Study Arms (1)

short course radiotherapy

EXPERIMENTAL

patients with metastatic rectal cancer will receive short course of radiotherapy befor staring chemotherapy

Radiation: short course radiotherapy

Interventions

short course radiotherapy RADIATION

short course palliative radiotherapy

short course radiotherapy

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Adenocarcinoma pathological evidence in rectal carcinoma.
• Metastatic unresectable rectal cancer.
• Symptomatic disease for at least one of the following signs: bleeding, pain, tenesmus, obstruction,

You may not qualify if:

• Previous radiotherapy.
• Concomitant chemotherapy.
• Previously created stoma.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Santucci C, Mignozzi S, Malvezzi M, Boffetta P, Collatuzzo G, Levi F, La Vecchia C, Negri E. European cancer mortality predictions for the year 2024 with focus on colorectal cancer. Ann Oncol. 2024 Mar;35(3):308-316. doi: 10.1016/j.annonc.2023.12.003. Epub 2024 Jan 28.

  PMID: 38286716 BACKGROUND

• Flyum IR, Mahic S, Grov EK, Joranger P. Health-related quality of life in patients with colorectal cancer in the palliative phase: a systematic review and meta-analysis. BMC Palliat Care. 2021 Sep 16;20(1):144. doi: 10.1186/s12904-021-00837-9.

  PMID: 34530833 BACKGROUND

• Yoo RN, Cho HM, Kye BH. Management of obstructive colon cancer: Current status, obstacles, and future directions. World J Gastrointest Oncol. 2021 Dec 15;13(12):1850-1862. doi: 10.4251/wjgo.v13.i12.1850.

  PMID: 35070029 BACKGROUND

• van Hooft JE, Veld JV, Arnold D, Beets-Tan RGH, Everett S, Gotz M, van Halsema EE, Hill J, Manes G, Meisner S, Rodrigues-Pinto E, Sabbagh C, Vandervoort J, Tanis PJ, Vanbiervliet G, Arezzo A. Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020. Endoscopy. 2020 May;52(5):389-407. doi: 10.1055/a-1140-3017. Epub 2020 Apr 7.

  PMID: 32259849 BACKGROUND

• Tissera NS, Freile B, Waisberg F, Esteso F, Galli M, Loria FS, Luca R, Pedraza II, Enrico DH, Chacon C, Huertas E, Chacon MR, O'Connor JM. Short-course radiotherapy for rectal cancer: real-world evidence in Argentina. Ecancermedicalscience. 2023 Jun 1;17:1555. doi: 10.3332/ecancer.2023.1555. eCollection 2023.

  PMID: 37396101 BACKGROUND

MeSH Terms

Conditions

Rectal Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Intestinal Diseases; Rectal Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor at radiotherapy department at south Egypt cancer institute

Study Record Dates

• First Submitted: July 17, 2024
• First Posted: July 26, 2024
• Study Start: August 1, 2024
• Primary Completion: August 1, 2024
• Study Completion (Estimated): December 1, 2026
• Last Updated: July 26, 2024

Record last verified: 2024-07