CHOICE to AVOID or RESIST

NCT06521021 | Not Yet Recruiting DMC

• 1 other identifier: STUDY00003315
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

This trials will formally test whether participants' active choice of self-regulatory strategies (AVOID or RESIST) leads to greater adherence to weight management strategies by comparing the CHOICE arms to the randomized arms of the parent intervention, AVOID/RESIST (IRB STUDY00001652: AVOID-RESIST).

Conditions

Overweight and Obesity

Outcome Measures

Primary Outcomes (1)

• Follow-up Completion

  We will continuously track the rate of 6-month follow-up completion as followed: actual follow-ups completed / expected follow-ups to be completed.

  Baseline, 6 Month

Secondary Outcomes (4)

• Height

  Baseline

• Demographics

  Baseline

• Drivers of preference, retention, and adherence

  Baseline, 6 Month

• Weight

  Baseline, 6 Month

Other Outcomes (1)

• Dietary intake and physical activity

  Baseline, 6 Month

Study Arms (2)

WW + Home modification and grocery delivery (AVOID)

OTHER

WW + modification of home food environment + online grocery shopping and delivery Arm assignment is selected by participant.

Behavioral: AVOID

WW + Inhibitory control training (RESIST)

OTHER

WW + daily gamified inhibitory control training Arm assignment is selected by participant.

Behavioral: RESIST

Interventions

AVOID BEHAVIORAL

Behavioral: Home food environment and grocery delivery (AVOID) Participants will receive coaching (Zoom and/or email/text) to modify their home food environment and alter cues to promote healthy food choices Behavioral: WW Participants assigned to all arms will receive of coaching (Zoom and/or email/text) and commercially-available weight management program focusing on diet, physical activity and mindset skills.

WW + Home modification and grocery delivery (AVOID)

RESIST BEHAVIORAL

Behavioral: Inhibitory control training (RESIST) Participants assigned to RESIST will receive coaching (Zoom and/or email/text) and gamified inhibitory control training. Behavioral: WW Participants assigned to all arms will receive coaching (Zoom and/or email/text) and commercially-available weight management program focusing on diet, physical activity and mindset skills.

WW + Inhibitory control training (RESIST)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or older
• BMI between 25-45 kg/m2
• Read, write, and speak English with acceptable visual acuity

You may not qualify if:

• Currently enrolled in weight loss interventions or undergoing bariatric surgery
• Pregnant women
• Individuals for whom weight loss may be contraindicated (e.g., unstable coronary artery disease, end-stage disease, active cancer treatment, uncontrolled insulin-dependent diabetes, portal hypertension, drug/alcohol abuse)
• Individuals who have pacemakers or other electronic medical device implantations
• Individuals with severe cognitive delays or visual/hearing impairment
• Individuals who are unable or unwilling to complete the study assessments / measurements
• Individuals currently subscribed to a meal delivery service who are unwilling to pause their subscription for the duration of the study

Sponsors & Collaborators

• Cedars-Sinai Medical Center: lead
• University of California, Riverside: collaborator
• Northeastern University: collaborator
• WW International Inc: collaborator
• The University of Tennessee, Knoxville: collaborator

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Sarah Salvy, PhD

  Cedars-Sinai Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Julissa Ruiz, BS

CONTACT

(310) 602-4169; julissa.ruiz@cshs.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: July 9, 2024
• First Posted: July 25, 2024
• Study Start: April 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share