Periodontal Disease and Salivary Mitofusin Levels

NCT06510608 | Not Yet Recruiting

• 1 other identifier: EUDF-OKUMUS-004
• Study Type: observational
• Target: 81
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this observational study is to find out whether there is a level difference in salivary mitofusin-1 and mitofusin-2 levels due to changes in periodontal status. The main question it aims to answer is:

• Do salivary mitofusin-1 and mitofusin-2 levels of periodontitis patients differ from healthy patients?
• Could salivary mitofusin-1 and mitofusin-2 levels be biomarkers for periodontal disease? Biochemical analysis will be performed on saliva samples taken at once from gingivitis or periodontitis patients and healthy individuals who apply to the periodontology clinic, at the initial stage of the treatment. There is no ongoing monitoring or second sampling.

Conditions

Periodontitis; Periodontal Diseases; Gingivitis

Outcome Measures

Primary Outcomes (3)

• Mitofusin-1 concentration

  Mitofusin-1 concentration in saliva, determined as a result of biochemical analysis

  Up to four weeks from start of work

• Mitofusin-2 concentration

  Mitofusin-2 concentration in saliva, determined as a result of biochemical analysis

  Up to four weeks from start of work

• IL-1B concentration

  IL-1B concentration in saliva, determined as a result of biochemical analysis

  Up to four weeks from start of work

Study Arms (3)

Healthy

Diagnostic Test: Biochemical analysis of saliva sample

Gingivitis

Diagnostic Test: Biochemical analysis of saliva sample

Periodontitis

Diagnostic Test: Biochemical analysis of saliva sample

Interventions

Biochemical analysis of saliva sample DIAGNOSTIC_TEST

It is the examination of saliva samples taken with biochemical methods. In this way, the substances in its content and the concentration of cytokines are analyzed.

Gingivitis; Healthy; Periodontitis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with gingivitis and periodontitis presenting to the periodontology clinic, as well as healthy individuals

You may qualify if:

• Being between the ages of 18 and 65.
• Willing to participate in the study and provide a saliva sample.
• Having a healthy periodontal condition, gingivitis, or periodontitis (Stage 3-4, Grade C).
• Having fasted from any food or drink (except water) for the past 2 hours prior to providing the saliva sample.
• Having refrained from brushing teeth or using mouthwash in the past 2 hours prior to providing the saliva sample.
• Not having any systemic diseases.
• Not currently taking any medications regularly.

You may not qualify if:

• Having used antibiotics within the last 6 months.
• Having received periodontal treatment within the last 6 months.
• Having fewer than 20 teeth (excluding third molars).
• Having any systemic diseases.
• Not smoking or having quit at least 5 years ago.

Sponsors & Collaborators

• Erzincan University: lead

Related Publications (1)

• Okumus OF, Kurt N, Kantarci A. Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study. BMC Oral Health. 2025 Oct 6;25(1):1542. doi: 10.1186/s12903-025-06932-0.

  PMID: 41053720 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

human saliva samples

MeSH Terms

Conditions

Periodontitis; Periodontal Diseases; Gingivitis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Infections; Gingival Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 5, 2024
• First Posted: July 19, 2024
• Study Start: July 25, 2024
• Primary Completion: August 25, 2024
• Study Completion: September 25, 2024
• Last Updated: July 19, 2024

Record last verified: 2024-07