Rewards Sensitivity After Brain Injury

NCT06510023 | Completed

• 1 other identifier: STU00213877
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

A study measuring rewards sensitivity in individuals with acquired brain injury at an acute rehabilitation level.

Conditions

Acquired Brain Injury

Keywords

Rewards Sensitivity; Motivation; Acquired Brain Injury; Electrodermal Activity

Outcome Measures

Primary Outcomes (3)

• Performance on a Cued Response Reaction Time Task, in each of the three rewards conditions (Dollar, Penny, No reward)

  Accuracy (percentage of correct responses) in a Cued Response Reaction task

  15 minutes

• Performance on a Cued Response Reaction Time Task, in each of the three rewards conditions (Dollar, Penny, No reward)

  Response time (time in milliseconds) in a Cued Response Reaction task

  15 minutes

• Electrodermal activity (EDA) before, during and after the Cued Response Reaction task

  Number of skin conductance responses (SCRs) before, during and after the task

  30 minutes

Study Arms (2)

Individuals with Acquired Brain Injury

EXPERIMENTAL

Measuring the effect of three different types of rewards (one dollar, one penny, and no reward) on performance in a cognitive test.

Behavioral: Type of reward presented

Non-impaired controls

OTHER

Measuring the effect of three different types of rewards (one dollar, one penny, and no reward) on performance in a cognitive test.

Behavioral: Type of reward presented

Interventions

Type of reward presented BEHAVIORAL

Three different types of rewards were presented to both groups during the computerized task: one dollar, one penny, and no reward.

Individuals with Acquired Brain Injury; Non-impaired controls

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals with ABI
• Diagnosis of Traumatic Brain Injury or Stroke, based on their medical records
• Age between 18-100
• Able to follow directions in English (measured informally during screening)
• Able to use at least one upper extremity (demonstrated by holding a pen)
• Mild-moderate or lesser diagnosis in cognitive-communication area
• Score of 25 or higher on the Orientation Log assessment
• Able to consent for participation in study (identifies through chart review)
• Capable of understanding and cooperating with the experimental procedures.
• Healthy participants
• Age of 18 to 100 years old
• Ability to follow directions in English
• Ability to use at least one upper extremity.

You may not qualify if:

• Individuals with ABI
• Additional diagnosis of a neurological disorder other than ABI
• Additional diagnosis of aphasia.
• Having cognitive or behavioral impairments that preclude participation in the experimental procedures
• Healthy Participants
• history of significant cerebrovascular or neurological disease including (but not limited to) meningitis, epilepsy and/or seizures, stroke, tumor, multiple sclerosis, meningitis, mental retardation, dementia.

Sponsors & Collaborators

• Shirley Ryan AbilityLab: lead

Study Sites (1)

Shirley Ryan AbilityLab

Chicago, Illinois, 60611, United States

Location

MeSH Terms

Conditions

Brain Injuries

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Shira Cohen-Zimerman, PhD

  Shirley Ryan AbilityLab

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Scientist

Model Details: 2X3 non-randomized, within-participant design.

Study Record Dates

• First Submitted: July 11, 2024
• First Posted: July 19, 2024
• Study Start: March 21, 2021
• Primary Completion: March 20, 2022
• Study Completion: March 20, 2022
• Last Updated: July 19, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)