Eccentric Exercise and Fatigue in Multiple Sclerosis

NCT06505421 | Recruiting

• 1 other identifier: 20240244
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to compare the impact of eccentric resistance training to traditional resistance training on fatigue in persons with multiple sclerosis (MS). The primary question this study is asking is the following: is eccentric resistance training more fatiguing than traditional resistance training in persons with MS?. Participants will be asked to come for two sessions for two weeks. In the first week, subjects will undergo a bout of either traditional or eccentric resistance training. The next day they will return to assess their level of fatigue. The following week the subject will return and undergo whatever type of training they did not experience the first week, and it's effects on fatigue will again be assessed. The difference between the subjects level of fatigue for either condition will be compared.

Conditions

Multiple Sclerosis; Fatigue

Keywords

Exercise; resistance training

Outcome Measures

Primary Outcomes (1)

• 6-Minute walk test

  Subject walks at best possible pace with or without assistive device for 6 minutes. Total distance walked as well as distance per minute is measured

  Pre-intervention and post intervention for each condition (eccentric and traditional strength training). There is a 36-48 hour period between the pre-intervention and post intervention for each condition

Secondary Outcomes (1)

• Visual analog scale of fatigue

  Pre-intervention and post-intervention for each condition (eccentric vs traditional strength training). There is a 36-48 hour period between the pre-intervention and post intervention for each condition

Study Arms (1)

Persons with Multiple sclerosis

Eccentric resistance training , traditional resistance training

Behavioral: Resistance training

Interventions

Resistance training BEHAVIORAL

Eccentric resistance training and tradional resistance training

Persons with Multiple sclerosis

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Ambulatory persons with MS

You may qualify if:

• Definitive diagnosis of Multiple Sclerosis.
• Ability to walk for 6 minutes continuously with or without assistive device
• Ability read, understand and sign and informed consent

You may not qualify if:

• Evidence of recent exacerbation in the last 2 months prior to starting the study
• Orthopedic, cardiopulmonary, or non -MS neurologic condition that could interfere with carrying out the study protocol

Sponsors & Collaborators

• Hunter College of City University of New York: lead

Study Sites (1)

Hunter College, Physical Therapy Department, City University of New York

New York, New York, 10010, United States

RECRUITING

Related Publications (3)

• Patrocinio de Oliveira CE, Moreira OC, Carrion-Yagual ZM, Medina-Perez C, de Paz JA. Effects of Classic Progressive Resistance Training Versus Eccentric-Enhanced Resistance Training in People With Multiple Sclerosis. Arch Phys Med Rehabil. 2018 May;99(5):819-825. doi: 10.1016/j.apmr.2017.10.021. Epub 2017 Nov 27.

  PMID: 29191417 BACKGROUND

• Wochatz M, Schraplau A, Engel T, Zecher MM, Sharon H, Alt Y, Mayer F, Kalron A. Application of eccentric training in various clinical populations: Protocol for a multi-centered pilot and feasibility study in people with low back pain and people with multiple sclerosis. PLoS One. 2022 Dec 22;17(12):e0270875. doi: 10.1371/journal.pone.0270875. eCollection 2022.

  PMID: 36548298 BACKGROUND

• Gauche E, Couturier A, Lepers R, Michaut A, Rabita G, Hausswirth C. Neuromuscular fatigue following high versus low-intensity eccentric exercise of biceps brachii muscle. J Electromyogr Kinesiol. 2009 Dec;19(6):e481-6. doi: 10.1016/j.jelekin.2009.01.006. Epub 2009 Feb 12.

  PMID: 19217311 BACKGROUND

MeSH Terms

Conditions

Multiple Sclerosis; Fatigue; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Herbert Karpatkin, DSc

CONTACT

212-396-7115; hkarpatk@hunter.cuny.edu

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: July 3, 2024
• First Posted: July 17, 2024
• Study Start: July 1, 2024
• Primary Completion: December 30, 2025
• Study Completion (Estimated): December 30, 2026
• Last Updated: July 17, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)