Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on the Efficacy of ICS or ICS/LABA

NCT06503939 | Enrolling By Invitation

• 1 other identifier: Z-2017-24-2301
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

This study collected 600 patients, evaluated whether patients had airway hyperreactivity, airway inflammation, specific types and allergic reactions, comprehensively analyzed and classified the causes of chronic cough in patients, and evaluated and compared the improvement of cough symptoms and quality of life after ICS or ICS/LABA treatment.

Conditions

Chronic Cough

Keywords

COVID-19

Outcome Measures

Primary Outcomes (1)

• The etiology of chronic cough was comprehensively analyzed and classified.

  2023.09-2024.12

Secondary Outcomes (1)

• To evaluate and compare cough symptoms and quality of life improvement after ICS or ICS/LABA treatment.

  2023.09-2024.12

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All persons who meet the above inclusion criteria and for whom no exclusion criteria exist

You may qualify if:

• Age ≥18 years old;
• A clear history of COVID-19 infection with a positive nucleic acid or antigen test before chronic cough;
• Persistent cough for more than 8 weeks after the acute phase of COVID-19 infection has disappeared;
• Chest X-ray and/or chest CT without significant evidence of lung disease;
• No history of chronic cough (\>8 weeks) prior to COVID-19 infection.

You may not qualify if:

• The patient refused pulmonary function and blood tests;
• The patient has previously been diagnosed with respiratory diseases with cough as one of the main symptoms, including cough variant asthma, allergic bronchitis, eosinophilic bronchitis, gastroesophageal reflux disease, chronic obstructive pulmonary disease, chronic bronchitis, bronchiectasis, interstitial lung disease, pulmonary/tracheobronchial tuberculosis, etc.;
• Patients who are pregnant or breastfeeding;
• The patient's medical records are incomplete;
• Patients lost to follow-up.

Sponsors & Collaborators

• Xiangya Hospital of Central South University: lead

Study Sites (1)

Xiangya Hospital Central South University

Changsha, Hunan, 410008, China

Location

MeSH Terms

Conditions

Chronic Cough; COVID-19

Condition Hierarchy (Ancestors)

Cough; Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases

Study Officials

• Juan Jiang, Doctor

  Xiangya Hospital of Central South University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2024
• First Posted: July 16, 2024
• Study Start: September 1, 2023
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: July 16, 2024

Record last verified: 2024-07

Locations

CN (1)