Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

NCT06501118 | Recruiting

• 1 other identifier: 24-0065
• Study Type: interventional
• Target: 3,600
• Locations: 1 country
• Sites: 1

Brief Summary

A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen saturation target range.

Conditions

Hypoxemia; Hypoxia; Hypoxic Respiratory Failure; Respiratory Failure; Acute Hypoxemic Respiratory Failure; Acute Hypoxic Respiratory Failure

Outcome Measures

Primary Outcomes (1)

• Ventilator Free Days

  The number of days the patient will be free of mechanical ventilation

  30 Days

Secondary Outcomes (11)

• instances of occult hypoxemia

  30 days

• ICU free days

  90 days

• Hospital free days

  90 DAYS

• 90 Day in hospital mortality

  90 days

• Time to Mortality to day 90

  90 Days

Study Arms (2)

Educational intervention

OTHER

SP02 target ranges will be 90-96%. Education about the specific oxygen targets will be provided to the clinical teams. Real time feedback on adherence to the Sp02 target range will be provided by virtual respiratory therapists.

Other: Education

Educational intervention Epic alert

OTHER

An education-based intervention that also focuses on mitigating Occult Hypoxemia in mechanically ventilated patients, and thus utilizes the same patient population. The second intervention will notify the clinical team to an abnormal laboratory result in real time. This laboratory result is already located in the patient's Epic chart under arterial blood gas (ABG), arterial oxygen saturation (Sa02) Patient level randomization will occur in Epic as 1. alert (notification) the providers of sustained occult hypoxemia or 2. silent alert The investigators are observing physician behavior in response to alerting them that a patient has occult hypoxemia via an Epic alert.

Behavioral: Epic notification alert

Interventions

Education OTHER

1\) Standardized materials to discuss the rationale and procedural aspects of the intervention, including details on the specific oxygen target-related modifications to the mechanical ventilation order-set prior to starting the intervention phase.

Educational intervention

Epic notification alert BEHAVIORAL

An education-based intervention that focuses on mitigating Occult Hypoxemia in mechanically ventilated patients and thus utilizes the same patient population. The second intervention will notify the clinical team to an abnormal laboratory result in real time. This laboratory result is already located in the patient's Epic chart under arterial blood gas (ABG), arterial oxygen saturation (Sa02) Patient level randomization will occur in Epic to as 1. alert (notification) the providers of sustained occult hypoxemia 2. silent alert

Educational intervention Epic alert

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Admission to ICU and requiring invasive mechanical ventilation

You may not qualify if:

• Transferred patients from outside the UCHealth system\*:
• Patients with pre-existing disease that requires chronic use of positive pressure ventilation delivered through a tracheostomy\*:
• Pregnant women:
• Prisoners
• Patients receiving mechanical ventilation for less than twelve hours

Sponsors & Collaborators

• University of Colorado, Denver: lead

Study Sites (1)

University of Colorado

Aurora, Colorado, 80045, United States

RECRUITING

Related Publications (30)

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MeSH Terms

Conditions

Respiratory Insufficiency; Hypoxia

Interventions

Educational Status

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Socioeconomic Factors; Population Characteristics

Study Officials

• Neil Aggarwal, MD

  University of Colorado, Denver

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Carrie Higgins, BSN

CONTACT

720-560-3037; carrie.higgins@cuanschutz.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2024
• First Posted: July 15, 2024
• Study Start: September 1, 2024
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): July 31, 2026
• Last Updated: April 17, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)