Postoperative Analgesis in Total Knee Arthroplasty

NCT06498557 | Completed

• 1 other identifier: GOKAEK 2024/10/1
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative analgesic treatment methods are applied to patients who have undergone knee arthroplasty. These applications are a routine part of the procedure. It is medically and ethically necessary. Postoperative analgesia applications are started during the intraoperative period and continued during the postoperative period. The analgesia protocol to be used is shaped by the characteristics of the patient and the skill and experience of the anesthesiologist. The scientifically accepted method is multimodel analgesia protocols. These protocols cover a wide range from paracetamol to opioids to peripheral and central blocks (methods such as suprainguinal fascia iliac block (SFIP), adductor block (ACB) and infiltration analgesia (IPACK) applied between the posterior elements of the knee and the popliteal artery). Our aim in this study is to evaluate the effects of analgesia protocols applied to patients undergoing knee arthroplasty surgery on inflammatory biomarkers (such as neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), systemic immune inflammation score (SII), lactate) obtained from routine blood and blood gas examinations in the first 24 hours of the postoperative period.

Conditions

Knee Arthroplasty

Keywords

POSTOPERATIVE PAIN; Knee Arthroplasty

Outcome Measures

Primary Outcomes (1)

• Postoperative pain

  Pain levels of patients will be evaluated with the Numerical Pain Scale (NRS) in the first 24 hours postoperatively.

  postoperative 24 hours

Secondary Outcomes (4)

• inflammatory mediators

  preoperative 24 hours

• inflammatory mediators

  preoperative 24 hours

• inflammatory mediators

  preoperative 24 hours

• inflammatory mediators

  preoperative 24 hours

Study Arms (2)

Group S

SFIP block will be applied for postoperative analgesic purposes

Other: Peripheral nerve block methods

Group IP

SFIP block will be applied for postoperative analgesic purposes

Other: Peripheral nerve block methods

Interventions

Peripheral nerve block methods OTHER

We apply different nerve blocks to patients for analgesic purposes after knee replacement surgery. These blocks are a combination of SFIP block and adductor channel block and iPACK block.

Group IP; Group S

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Among patients who had elective knee replacement surgery, those who underwent postoperative nerve block

You may qualify if:

• years old
• ASA I,II,III patients
• Patients who will undergo elective surgery

You may not qualify if:

• Patients undergoing emergency surgery
• Patients with bleeding diathesis
• Those who are allergic or sensitive to local anesthetics and opioid drugs,
• Those who use gabapentinoids
• Patients with neurocognitive disorders,
• Patients with chronic organ failure,
• Mothers with suspected pregnancy, pregnant or breastfeeding mothers
• Patients using opioids
• Those who use steroids
• Those with a history of substance use

Sponsors & Collaborators

• Senay Canikli: lead

Study Sites (1)

SAMSUN UNIVERSITY Samsun Training and research hospital

Samsun, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Senay canikli adıgüzel

  Samsun University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: June 29, 2024
• First Posted: July 12, 2024
• Study Start: July 22, 2024
• Primary Completion: October 4, 2024
• Study Completion: October 5, 2024
• Last Updated: November 25, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)