Effectivity Gas Extraction to Prevent Anesthesiologists Waste Gas Exposure of Sevofluorane During Pediatric Induction

NCT06487169 | Not Yet Recruiting

• 1 other identifier: 0072-24-BNZ
• Study Type: observational
• Target: 10
• Locations: 0 countries
• Sites: N/A

Brief Summary

Inhalational anesthetics (IAs) are widely used in surgery and experimental research. IAs, in addition to their medical significance, are a major source of chemical contamination in the operating rooms (ORs).Exposure to IAs in ORs personnel results in reproductive effects, including infertility , spontaneous abortions , congenital diseases , psychological and neurological disturbances, hepatotoxicity , and genotoxicity .The metabolites of sevoflurane include hexafluoroisopropanol (HFIP) and inorganic fluoride (IF). The hospital's engineering department installed an air extractor with the objective to reduce the anesthetic gas concentrations during pediatric anesthesia induction. The investigators are interested in checking if the new technique also has an influence in decreasing the level of Sevoflurane breathed in by the anesthesiologist.The investigators purpose is to detect the presence of desfluoroisopropanolol in the urine of ten anesthesiologists who used sevoflurane to induce children with a mask during an eight-hour session in the induction room (IR) One session will be conducted without the use of the air extractor and the other with the air extractor. After 24 hours, a urine sample will be taken and sent to the Toxicology Unit.

Conditions

Unrecognized Condition

Keywords

sevofluorane,; hexacloroisopropanolol

Outcome Measures

Primary Outcomes (1)

• Presence of sevoflurane metabolite, hexafluoroisopropanol in urine

  hexafluoroisopropanol is the metabolism of the sevofluorane

  up to 24 weeks

Interventions

Urine analysis to determine the presence of hexafluoroisopropanol DIAGNOSTIC_TEST

analysis of sevoflurane metabolites in urine

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Ten anesthesiologists that work in Pediatric Induction Room using anesthesia induction with sevoflurane delivery with mask

Sponsors & Collaborators

• Bnai Zion Medical Center: lead

Biospecimen

Retention: SAMPLES WITHOUT DNA

Anesthesiologists

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor

Study Record Dates

• First Submitted: June 24, 2024
• First Posted: July 5, 2024
• Study Start: August 1, 2024
• Primary Completion: December 31, 2024
• Study Completion: January 31, 2025
• Last Updated: July 5, 2024

Record last verified: 2024-07