Validation of the Experience Sampling Dietary Assessment Method

NCT06485960 | Recruiting DMC

• 2 other identifiers: S68363C3/22/050
• Study Type: observational
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

A new dietary assessment method was developed based on the Experience Sampling Methodology. In order to use this newly developed Experience Sampling Dietary Assessment Method (ESDAM) in research and clinical practice as a valid and reliable method to measure dietary intake the ESDAM needs to be validated against objective biomarkers and reference methods.

Conditions

Validation Study

Keywords

Dietary assessment; Validation; Experience Sampling; digital health; digital biomarkers; doubly-labeled water; ESM

Outcome Measures

Primary Outcomes (4)

• Daily dietary energy intake based on the Experience Sampling Dietary Assessment Method

  Daily dietary energy intake estimated by the Experience Sampling Dietary Assessment Method (ESDAM) compared to the Doubly-labeled Water Method

  2 weeks

• Daily dietary protein intake based on the Experience Sampling Dietary Assessment Method

  Daily dietary protein intake estimated by the Experience Sampling Dietary Assessment Method (ESDAM) compared to urinary nitrogen

  2 weeks

• Daily energy expenditure derived from the doubly-labeled water method

  Daily energy expenditure (kcal/day) measured by the doubly-labeled water method

  2 weeks

• Daily dietary protein intake based on urinary nitrogen analysis

  Daily dietary protein intake based on urinary nitrogen analysis

  2 weeks

Secondary Outcomes (5)

• Dietary intake based on Experience Sampling Dietary Assessment Method

  2 weeks

• Dietary intake based on 24-hour dietary recalls

  2 weeks

• Serum Beta-carotenoid concentration

  4 weeks

• Erythrocyte membrane fatty acid composition

  4 weeks

• Plasma polyphenol concentration

  4 weeks

Other Outcomes (2)

• Timing of glucose peaks

  2 weeks

• Timing of eating-related motion

  2 weeks

Study Arms (1)

YONAS 1

ESDAM validation

Other: ESDAM validation

Interventions

ESDAM validation OTHER

* 3\* 24-Hour Dietary Recalls * Experience Sampling Dietary Assessment Method (mobile application) * Continuous Blood Glucose Monitoring * Wrist- worn motion sensors * Doubly-labeled water administration * Blood drawings (Erythrocyte Membrane Fatty Acid composition, Carotenoids, polyphenols) * Urine sampling (Doubly-labeled water, urinary nitrogen)

YONAS 1

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adult volunteers

You may qualify if:

• Signed informed consent
• Having a smartphone and being capable of using the smartphone and apps
• Having a freezer at home
• Sufficient knowledge of the Dutch language to understand and participate in the study
• Having a stable body weight (body weight not changed by 5% last 3 months)
• Not aiming to gain or lose weight during the study period

You may not qualify if:

• Pregnant or lactating women
• Not following a specific diet for medical reasons (i.e. coeliac disease)

Sponsors & Collaborators

• KU Leuven: lead

Study Sites (1)

KU Leuven

Leuven, Vlaams Brabant, 3000, Belgium

RECRUITING

Related Publications (1)

• Verbeke J, Verbeke K, Van der Schueren B, Vangoitsenhoven R, Matthys C. Protocol of the validation of the experience sampling-based dietary assessment method (ESDAM) against doubly labeled water, urinary protein, and biomarkers. Nutr J. 2025 Nov 5;24(1):169. doi: 10.1186/s12937-025-01232-3.

  PMID: 41194100 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood

Study Officials

• Christophe Matthys, PhD

  KU Leuven/UZ Leuven

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christophe Matthys, PhD

CONTACT

+32 16 34 26 55; christophe.matthys@uzleuven.be

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor dr.

Study Record Dates

• First Submitted: June 20, 2024
• First Posted: July 3, 2024
• Study Start: October 9, 2025
• Primary Completion: February 1, 2026
• Study Completion: March 1, 2026
• Last Updated: December 10, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)