Value of Advanced MRI Techniques in the Assessment of Endometriosis

NCT06481982 | Withdrawn

• 1 other identifier: Advanced MRI Endometriosis
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Endometriosis is a common gynaecological disease, mostly in women of reproductive age, with a prevalence of about 10 %, which is defined by the presence of endometrial-type tissue outside the uterine cavity. Endometriosis is usually limited to the abdominal and especially the pelvic cavity, extra-abdominal lesions are rare. Within the pelvis it shows a wide variety of locations predominantly affecting the ovaries and the uterus or the peritoneum, uterine ligaments and other pelvic structures. Traditionally, there are three major phenotypes of endometriosis: Ovarian endometrioma (OMA), superficial peritoneal endometriosis (SPE), and deep infiltrating endometriosis (DIE). A lesion is considered a DIE, if it shows infiltration deeper than 5 mm into the peritoneum. The ectopic endometrial implants may induce inflammatory processes, causing scar tissue formation, adhesions, and consequently pelvic anatomy distortion. The prospective study aims to investigate the value of advanced MRI techniques to improve the assessment of pelvic endometriosis.

Conditions

Endometriosis

Outcome Measures

Primary Outcomes (1)

• Diagnostic Accuracy

  Diagnostic accuracy of different MRI sequences in comparison to ultrasound assessment and/or laparoscopy as standard of reference.

  5 years

Interventions

MRI DIAGNOSTIC_TEST

MRI sequences

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Women undergoing routine MRI for endometriosis staging.

You may qualify if:

• Patients who undergo clinically indicated MR imaging for endometriosis evaluation.

You may not qualify if:

• Non-MRI compatible devices/implants

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich

Zurich, Canton of Zurich, 8091, Switzerland

Location

MeSH Terms

Conditions

Endometriosis

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2024
• First Posted: July 1, 2024
• Study Start: March 1, 2026
• Primary Completion (Estimated): August 1, 2029
• Study Completion (Estimated): August 1, 2029
• Last Updated: September 29, 2025

Record last verified: 2025-09

Locations

CH (1)