Trials Sponsors Conditions Drugs Pricing

Conditions

Depression Functional Dyspepsia

Outcome Measures

Primary Outcomes (3)

Depressionsymptom scale
Hamilton Depression Scale is assessed patients' depressive symptoms pre- and post-treatment.
Pre-treatment and 4 weeks of treatment
FD symptom scale
The overall score method for the main symptoms was used, and the overall symptoms included postprandial fullness and discomfort, early satiety, mid-upper abdominal pain, and burning sensation in the mid-upper abdomen. The degree and frequency of symptoms were observed before and after treatment
Pre-treatment and 4 weeks of treatment
Chinese Medicine Symptoms
Evaluation of Chinese medicine symptoms before and after treatment using the Chinese Medicine Symptoms Score Scale
Pre-treatment and 4 weeks of treatment

Secondary Outcomes (1)

Adverse events during treatment
Pre-treatment and 4 weeks of treatment

Study Arms (2)

rabeprazole sodium enteric-coated tablets or mosapride citrate

EXPERIMENTAL

For epigastric pain syndrome, Rabeprazole sodium enteric-coated tablets were given as 20mg/dose, 2 times/day. Postprandial discomfort syndrome was treated with mosapride citrate, 5mg/dose, 3 times/day, orally before meals. The treatment lasted for 4 weeks.

Drug: Rabeprazole sodium enteric-coated tabletsDrug: mosapride citrate

Chinese medicine combination group

EXPERIMENTAL

In the Chinese medicine combination group, 3g of Zuojinwan was added to the western medicine group twice a day for 4 weeks.

Drug: zuojinwanDrug: Rabeprazole sodium enteric-coated tabletsDrug: mosapride citrate

Interventions

zuojinwanDrug

In the Chinese medicine combination group, 3g of Zuojinwan was added to the western medicine group twice a day for 4 weeks.

Also known as: zuojin pills

Chinese medicine combination group

Rabeprazole sodium enteric-coated tabletsDrug

For epigastric pain syndrome

Eligibility Criteria

Age18 Years - 65 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

(1) Aged between 18 and 65 years; (2) Fulfilment of western medical diagnostic criteria for FD; (3) Meeting the diagnostic criteria for mild depression; (4) Comply with the diagnostic criteria of Liver and Stomach Depression and Heat Disorder in Chinese medicine; (5) A score of 7-17 on the 17-item Hamilton Depression Scale (HAMD-17) (7-17 being mild depression); (6) Good compliance and autonomous behaviour; (7) Enrolled patients must have a diagnosis of gastroscopy, and the gastroscopic diagnosis should be no abnormality or chronic gastritis, no obvious erosion can be seen under the microscope, and there is no obvious atrophy, intestinal epithelial metaplasia, or heterogeneous hyperplasia in the pathological examination. It should be based on the results of gastroscopy in a tertiary-level hospital within 6 months.

Sponsors & Collaborators

Nanjing First Hospital, Nanjing Medical University
Otherlead

MeSH Terms

Conditions

Depression

Interventions

mosapride

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehavior

Study Officials

wanli liu
The First Affiliated Hospital with Nanjing Medical University
STUDY DIRECTOR

Central Study Contacts

yan wang

CONTACT

19801295220 292615568@qq.com

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: PARTICIPANT
Purpose: BASIC SCIENCE
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

June 25, 2024

First Posted

July 1, 2024

Study Start

June 30, 2024

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

February 27, 2025

Zuojin Wan Combined With Rabeprazole or Mosapride for the Treatment of Functional Dyspepsia Combined With Depression

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (3)

Secondary Outcomes (1)

Study Arms (2)

rabeprazole sodium enteric-coated tablets or mosapride citrate

Chinese medicine combination group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (3)

Secondary Outcomes (1)

Study Arms (2)

rabeprazole sodium enteric-coated tablets or mosapride citrate

Chinese medicine combination group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record