Eccentric Cycling Exercise During Pulmonary Rehabilitation Pulmonary Vascular Disease
1 other identifier
interventional
22
1 country
2
Brief Summary
Eccentric cycling allows high intensities with low metabolic costs. Therefore the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with PVD
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2024
Typical duration for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 29, 2024
CompletedFirst Submitted
Initial submission to the registry
May 31, 2024
CompletedFirst Posted
Study publicly available on registry
June 28, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 1, 2026
June 28, 2024
June 1, 2024
2 years
May 31, 2024
June 24, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
peak exercise capacity
3 weeks
Secondary Outcomes (16)
Peak oxygen uptake
3 weeks
ventilatory equivalent for CO2
3 weeks
Finger pulseoximetry
3 weeks
6 minute walk distance
3 weeks
systolic pulmonary artery pressure
3 weeks
- +11 more secondary outcomes
Study Arms (2)
Eccentric cycling exercise
EXPERIMENTALConcentric cycling exercise
ACTIVE COMPARATORInterventions
Instead of normal cycling, patients will exercise on the eccentric bike.
Eligibility Criteria
You may qualify if:
- Diagnosed with PVD, either PAH or CTEPH according to recent guidelines
- Stable medication for at least 1 month
- Age 18 to 85 years
- No resting hypoxemia (PaO2 \>7.3kPa)
You may not qualify if:
- Any co-morbidity that limits the patient to participate the full rehabilitation
- Enrollments in other trials with active treatments
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Rehabilitation clinic Barmelweid
Erlinsbach, 5017, Switzerland
University Hospital Zurich, Pneumology
Zurich, Switzerland
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr. med.
Study Record Dates
First Submitted
May 31, 2024
First Posted
June 28, 2024
Study Start
May 29, 2024
Primary Completion (Estimated)
June 1, 2026
Study Completion (Estimated)
July 1, 2026
Last Updated
June 28, 2024
Record last verified: 2024-06