Risk Factors for Postoperative Cough in Patients Undergoing Thoracoscopic Lung Resection

NCT06476249 | Recruiting

• 1 other identifier: 202404101CAP
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Lung cancer, as the main cause of cancer-related deaths in both males and females, is a great risk to human health. Pulmonary resection is the most applicable to early-stage lung cancer diagnoses and considered the best curative options. Coughing is a prominent symptom among postoperative complications, with approximately 18%-50% of patients experiencing persistent coughing after surgery. This study is a prospective observational study and is expected to be carried out in a large tertiary hospital. This cohort is expected to include 1000 participants for three years. Patients with pulmonary nodules on chest CT will be divided into two groups based on the presence or absence of cough symptoms on admission. The investigators decided whether to include patients in this cohort study strictly based on the inclusion and exclusion criteria. The severity of cough, the trajectory of cough change, and the physiological and social burden caused by cough will be reflected by the results of LCQ-MC, CSS, HARQ, and VAS. LCQ-MC, CSS, HARQ, and VAS are just a few of the questionnaires that are widely used to investigate the cough and severity of the respondent. The included variables included age, gender, Height, Weight, education level, smoking history, alcohol history, preoperative lung function, nodule size, preoperative and postoperative blood routine (such as white blood cell count, neutrophil count, etc.), blood biochemistry (such as C-reactive protein, PCT, etc.), liver and kidney function test results, surgical method, surgical site, operation duration, anesthesia method, anesthesia duration, lymph node dissection, pathological results, chest tube caliber, number of days of catheterization, use of cough drugs, use of non-steroidal anti-inflammatory drugs, Number of days in hospital and number of outpatient visits due to cough.

Conditions

Lung Cancer

Keywords

cough after pulmonary resection; thoracoscopic lung resection

Outcome Measures

Primary Outcomes (2)

• The score value of Mandarin Chinese version of the Leicester Cough Questionnaire

  Mandarin Chinese version of the Leicester Cough Questionnaire is a globally recognized questionnaire for assessing the severity of cough

  On the 3rd,1 month and Half a year postoperatively

• The score value of visual analogue scale

  The score value of visual analogue scaleis a globally recognized questionnaire for assessing the severity of cough

  On the 3rd, 7th, 11th, 15th, 1 month, and half a year after surgery, respectively

Secondary Outcomes (1)

• The score value of Hull airway reflux questionnaire

  On the 3rd,1 month and Half a year postoperatively

Study Arms (2)

cough

Patients who met the inclusion and exclusion criteria and underwent thoracoscopically assisted pneumonectomy with postoperative cough

Other: without

Uncough

Patients who met the inclusion and exclusion criteria and underwent thoracoscopically assisted pneumonectomy without postoperative cough

Other: without

Interventions

without OTHER

without

Uncough; cough

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The participants in this study are from the 920th Hospital. Patients aged 18 years or older and less than or equal to 70 years of age who underwent surgery with video-assisted thoracoscopic pneumonectomy.

You may qualify if:

• ● Patients aged 18 years or older and less than or equal to 70 years of age who underwent surgery with video-assisted thoracoscopic pneumonectomy.

You may not qualify if:

• Pre-existing cough before surgery (e.g. asthma, taking ACEI Drugs, etc.)
• Distant metastasis of tumor
• Combined pregnancy or breastfeeding
• Combined with other systemic major diseases (such as malignant swelling, chronic liver insufficiency, chronic renal insufficiency, etc.)
• Suffering from mental illness
• Refusal of follow-up or incomplete clinical information

Sponsors & Collaborators

• Hematology department of the 920th hospital: lead

Study Sites (1)

the 920th Hospital of the Joint Logistics Support Force

Kunming, Yunnan, 223964, China

RECRUITING

Related Publications (1)

• Zhang R, Yang X, He T, Men B, Nian ZX, Yu J, Zhang YF, Liu XK, Zhang X, He GH, Cai WK. Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol. BMJ Open. 2025 Jun 30;15(6):e096934. doi: 10.1136/bmjopen-2024-096934.

  PMID: 40588380 DERIVED

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Wenk Cai, doctor

  the Vice-President of the 920th Hospital of the Joint Logistics Support Force

  STUDY CHAIR

Central Study Contacts

Rong Zhang, Master

CONTACT

+8613808743327; zhangrong00626@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 10, 2024
• First Posted: June 26, 2024
• Study Start: March 1, 2024
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: June 28, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)