Association Between Preoperative Hyperglycemia and Postoperative Delirium in Geriatric Hip Fracture Patients

NCT06473324 | Completed

• 1 other identifier: DDZX-20231121
• Study Type: observational
• Target: 2,031
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study aims to collect electronic medical record data from Dandong central hospital spanning from January 2013 to November 2023. The collected data does not contain any personally identifiable information or breach privacy. Additionally, this study design does not involve active intervention measures or patient recruitment. The research aims to investigate the correlation between preoperative blood glucose levels in elderly hip fracture patients and postoperative delirium.

Conditions

Postoperative Delirium; Hip Fractures; Hyperglycemia

Outcome Measures

Primary Outcomes (1)

• Number of Participants with Postoperative Delirium

  Postoperative Delirium (POD) manifests as acute cognitive dysfunction and consciousness disorder, characterized by changes in attention or consciousness that cannot be attributed to pre-existing cognitive impairments. Typical symptoms include hallucinations, delusions, agitated behavior, disordered speech, decreased attention, confusion, unclear consciousness, and disrupted sleep-wake cycles. Moreover, POD typically occurs within the first five days after surgery, particularly within the initial 48 hours, and exhibits significant fluctuations.

  up to 2 months

Study Arms (2)

hyperglycaemia group

Blood glucose level ≥ 6.1 mmol/L

hypoglycaemic group

Blood glucose level \< 6.1 mmol/L

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 2,031 electronic medical records were gathered. Following stringent inclusion and exclusion criteria, a retrospective cohort study was conducted on 1,440 patients with hip fracture. Among them, 783 patients (54.4%) exhibited preoperative persistent hyperglycemia (serum glucose levels ≥ 6.1 mmol/L on multiple occasions), while 275 patients (19.1%) experienced postoperative delirium. The average age of the included geriatric hip fracture patients was 74.7 ± 9.8 years, with males comprising 39.7% of the sample.

You may qualify if:

• \) Patients who have undergone surgical treatment for hip fractures.

You may not qualify if:

• Multiple or pathological hip fractures.
• Emergent surgery.
• Age below 60 years.
• Incomplete electronic medical records or preoperative blood glucose levels were assessed fewer than two times.
• Presence of neurological and psychiatric disorders, except dementia.

Sponsors & Collaborators

• Wenbo Ding: lead

Study Sites (1)

Dandong Central Hospital

Dandong, Liaoning, 118002, China

Location

Related Publications (1)

• Wang W, Zhang Y, Yao W, Tang W, Li Y, Sun H, Ding W. Association between preoperative persistent hyperglycemia and postoperative delirium in geriatric hip fracture patients. BMC Geriatr. 2024 Jul 8;24(1):585. doi: 10.1186/s12877-024-05192-x.

  PMID: 38977983 DERIVED

MeSH Terms

Conditions

Emergence Delirium; Hip Fractures; Hyperglycemia

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 18, 2024
• First Posted: June 25, 2024
• Study Start: November 21, 2023
• Primary Completion: January 1, 2024
• Study Completion: January 3, 2024
• Last Updated: June 25, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)