Tailoring Upper Limb Exercise Advice for People With Parkinson Disease

NCT06472843 | Not Yet Recruiting

• 1 other identifier: 001
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The investigators will explore the impact of hand cycling, on hand function in people with Parkinson's Disease (PD). The study will compare the effects of two different hand cycling approaches-steady-state and interval efforts-on improving hand dexterity in people with PD. Conducted as a clinical trial, it aims to understand if a single session of hand cycling can temporarily enhance hand function and if the nature of the exercise influences the benefit.

Conditions

Parkinson Disease; Upper Limb; Aerobic Exercise

Outcome Measures

Primary Outcomes (1)

• 9-hole pegboard test

  Time to complete the 9-hole pegboard test with the clinically more affected hand.

  Through study completion, an average of 9 months

Secondary Outcomes (5)

• Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) score

  Through study completion, an average of 9 months

• Finger tapping speed

  Through study completion, an average of 9 months

• Perceived exertion

  Through study completion, an average of 9 months

• Positive Affect

  Through study completion, an average of 9 months

• Enjoyment

  Through study completion, an average of 9 months

Study Arms (2)

Interval

Participants in the interval condition will begin with a gradual one minute warm up effort with a ramp in the resistance gradually increasing from 0 watts to 60% of their peak power output (Wpeak) over 1 minute. They will then perform five sets of high intensity intervals with rest between these efforts. The intervals will be at 100% Wpeak for 15 seconds followed by 60% Wpeak for 45 seconds. During the work intervals participants will be encouraged to apply the highest cadence they can produce for the 15 second interval and resume a freely chosen cadence in the rest periods. After five interval repetitions (5 minutes) they will gradually warm-down from 60% Wpeak to 0 watts over 1 minute.

Behavioral: Exercise Intervention

Steady State

Participants in the steady state condition will begin the intervention with a gradual one minute warm up effort with a ramp in the resistance gradually increasing from 0 watts to 70% of their Wpeak over 1 minute. They will then continue at this resistance level at a freely chosen cadence for 5 minutes, after which they will gradually warm-down to 0 watts over 1 minute.

Behavioral: Exercise Intervention

Interventions

Exercise Intervention BEHAVIORAL

The exercise session is a fitness test using a hand bike, and you will be randomly assigned to one of two exercise sessions. The fitness test and exercise sessions are short (less than 10 minutes).

Interval; Steady State

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with Parkinson Disease that are medically fit to perform a brief session of aerobic exercise.

You may qualify if:

• Adults over 19 with a clinical diagnosis of PD.

You may not qualify if:

• Medical contraindication to aerobic exercise, such as unstable cardiovascular disease, or physical disability that precludes arm exercise.
• Individuals will be excluded if, upon screening with the Canadian Society for Exercise Physiology (CSEP) Get Active Questionnaire and International Physical Activity Questionnaire Short Form (IPAQ-SF) a need for further evaluation before exercise is identified

Sponsors & Collaborators

• University of British Columbia: lead

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Assistant Professor, University of British Columbia Southern Medical Program

Study Record Dates

• First Submitted: April 23, 2024
• First Posted: June 25, 2024
• Study Start: July 1, 2024
• Primary Completion: September 1, 2024
• Study Completion: September 1, 2024
• Last Updated: June 25, 2024

Record last verified: 2024-06