Fat Oxidation Capacity in Patients With Post Covid-19 Syndrome
Analysis of Fat Oxidation Capacity During Cardiopulmonary Exercise Testing Indicates Long-lasting Metabolic Disturbance in Patients With Post-COVID-19 Syndrome
1 other identifier
observational
187
1 country
1
Brief Summary
Post-COVID-19 Syndrome (PCS) is characterized by symptoms, including fatigue, reduced physical performance, dyspnea, cognitive impairment, and psychological distress. The mechanisms underlying the onset and severity of PCS point to mitochondrial dysfunction as significant contributor. This study examined fat oxidation as a function of mitochondrial capacity during exercise.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2021
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
May 21, 2024
CompletedFirst Submitted
Initial submission to the registry
June 19, 2024
CompletedFirst Posted
Study publicly available on registry
June 21, 2024
CompletedJune 25, 2024
June 1, 2024
2.2 years
June 19, 2024
June 21, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in Fat Oxidation Rate
Fat oxidation will be assessed by breath-by-breath spiroergometry
Baseline and week 4 (i. e. before discharge)
Secondary Outcomes (2)
Change in Carbohydrate Oxidation Rate
Baseline and week 4 (i. e. before discharge)
Change in Fatigue
Baseline and week 4 (i. e. before discharge)
Study Arms (1)
Post-Covid-19 Syndrome Patients
Interventions
Patients performed regular physical exercise during inpatient rehabilitation
Eligibility Criteria
Patients with Post-COVID-19 syndrome who are referred to Clinic Königsfeld for inpatient medical rehabilitation and who are willing to participate in the study and give their written informed consent. Inclusion criteria were a history of (at least one) COVID-19 infection (positive PCR test at the time of infection), and ongoing or newly expressed performance deficits lasting for at least 3 months prior to recruitment.
You may qualify if:
- a history of (at least one) Covid-19 infection
- ongoing or newly expressed performance deficits lasting for at least 3 months prior to recruitment
- referral to inpatient rehabilitation
- signed informed consent
You may not qualify if:
- unstable condition
- incapable of understanding study information
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Clinic Königsfeld
Ennepetal, North Rhine-Westphalia, 58256, Germany
Related Publications (1)
Garbsch R, Schafer H, Mooren FC, Schmitz B. Analysis of fat oxidation capacity during cardiopulmonary exercise testing indicates long-lasting metabolic disturbance in patients with post-covid-19 syndrome. Clin Nutr. 2024 Dec;43(12):26-35. doi: 10.1016/j.clnu.2024.10.010. Epub 2024 Oct 11.
PMID: 39423759DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 19, 2024
First Posted
June 21, 2024
Study Start
April 1, 2021
Primary Completion
June 30, 2023
Study Completion
May 21, 2024
Last Updated
June 25, 2024
Record last verified: 2024-06