Influence of TyG Index and TG/HDL-C Ratio on Fetal Macrosomia

NCT06463990 | Completed

• 1 other identifier: AECH-FIRATLIGIL-001
• Study Type: observational
• Target: 302
• Locations: 1 country
• Sites: 1

Brief Summary

Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus. The triglyceride level and other lipids increase slightly during pregnancy. This increase has a positive effect on the development of the fetus. However, an excessive increase in lipid levels can cause some metabolic disorders such as gestational diabetes and increase feto-maternal morbidity/mortality. While some existing studies have shown that elevated triglyceride levels can cause fetal macrosomia, others have found no correlation between these two variables. The ratio of triglycerides to HDL is a widely used marker for lipid disorders. In addition, the triglyceride-glucose index is also an index used to detect insulin resistance.

Conditions

Fetal Macrosomatia; Lipid Metabolism Disorders; Hyperlipidemias

Keywords

Fetal macrosomia; Nulliparous; Triglyceride; TyG index

Outcome Measures

Primary Outcomes (2)

• The TyG index

  The triglyceride-glucose index was determined using the formula Ln \[fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2\], with blood samples taken from pregnant women in the third trimester.

  between 28 and 40 weeks of pregnancy

• The triglyceride to high density lipoprotein cholesterol ratio

  The triglyceride to high density lipoprotein cholesterol ratio was calculated from the blood samples taken from pregnant women in the third trimester.

  between 28 and 40 weeks of pregnancy

Secondary Outcomes (1)

• HOMA-IR

  between 28 and 40 weeks of pregnancy

Study Arms (2)

Study group

women with macrosomic newborns

Other: TyG index

Control group

women with non-macrosomic newborns

Other: TyG index

Interventions

TyG index OTHER

association between TyG index and triglyceride to high-density lipoprotein cholesterol ratio with fetal macrosomia

Also known as: Triglyceride to high-density lipoprotein cholesterol ratio

Control group; Study group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: pregnant women
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The singleton pregnant women who delivered a macrosomic newborn were included in the study group (Group I) and the singleton pregnant women who delivered a non-macrosomic fetus were included in the control group (Group II). For each pregnant woman who met the inclusion and exclusion criteria and was eligible for Group I, the first patient in the ranking order of the files who met the criteria previously mentioned in the Materials and Methods section was selected for Group II.

You may qualify if:

• Screening for fetal macrosomia was based on the term defined according to the standards of the American College of Obstetricians and Gynecologists (ACOG).
• Low-risk nulliparous singleton pregnant women.
• Age between 18 and 40 years old

You may not qualify if:

• Post-term pregnancies
• Hospitalized for preterm labor or preterm premature rupture of membranes.
• Gestational diabetes mellitus, diabetes mellitus type I - type II.
• Pregnant women with fetal growth restriction, hypertensive pregnancy disorders, familial hypercholesterolemia and hyperlipidemia.
• Multiparous pregnant women
• Multiple pregnancies
• Pregnant women with chronic diseases.
• Pregnant women with impaired liver function;
• Pregnant women with body mass index \<25 and \>40 kg/m2.

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (1)

Ankara Etlik City Hospital

Ankara, Yenimahalle, Turkey (Türkiye)

Location

Related Publications (5)

• Macrosomia: ACOG Practice Bulletin, Number 216. Obstet Gynecol. 2020 Jan;135(1):e18-e35. doi: 10.1097/AOG.0000000000003606.

  PMID: 31856124 RESULT

• Poveda NE, Garces MF, Darghan AE, Jaimes SAB, Sanchez EP, Diaz-Cruz LA, Garzon-Olivares CD, Parra-Pineda MO, Bautista-Charry AA, Muller EA, Alzate HFS, Acosta LMM, Sanchez E, Ruiz-Parra AI, Caminos JE. Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study. Int J Endocrinol. 2018 Aug 6;2018:8956404. doi: 10.1155/2018/8956404. eCollection 2018.

  PMID: 30158976 RESULT

• Babic N, Valjevac A, Zaciragic A, Avdagic N, Zukic S, Hasic S. The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2. Med Arch. 2019 Jun;73(3):163-168. doi: 10.5455/medarh.2019.73.163-168.

  PMID: 31404127 RESULT

• Barat S, Ghanbarpour A, Bouzari Z, Batebi Z. Triglyceride to HDL cholesterol ratio and risk for gestational diabetes and birth of a large-for-gestational-age newborn. Caspian J Intern Med. 2018 Fall;9(4):368-375. doi: 10.22088/cjim.9.4.368.

  PMID: 30510652 RESULT

• Firatligil FB, Tuncdemir S, Sucu S, Reis YA, Ozkan S, Dereli ML, Sucu ST, Engin-Ustun Y. Association of the triglyceride-glucose index and the ratio of triglyceride to high-density lipoprotein cholesterol with fetal macrosomia in nulliparous pregnant women: a prospective case-control study. BMC Pregnancy Childbirth. 2025 Feb 17;25(1):175. doi: 10.1186/s12884-025-07317-5.

  PMID: 39962459 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Singleton nulliparous pregnant women who had performed an oral glucose challenge test (OGCT) between 24 and 28 weeks' gestation with a result of less than 140 mg/dL had blood samples taken at 8:00 am on the first visit to the outpatient clinic in the third trimester after an 8-hour fasting state

MeSH Terms

Conditions

Lipid Metabolism Disorders; Hyperlipidemias; Fetal Macrosomia

Condition Hierarchy (Ancestors)

Metabolic Diseases; Nutritional and Metabolic Diseases; Dyslipidemias; Diabetes, Gestational; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Fetal Diseases; Pregnancy in Diabetics; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases; Birth Weight; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Yaprak Engin-Ustun, Prof

  Etlik Zubeyde Hanim Women's Health Education and Research Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist doctor in obstetrics and gynecology and Fellow student in Perinatology

Study Record Dates

• First Submitted: June 8, 2024
• First Posted: June 18, 2024
• Study Start: January 1, 2023
• Primary Completion: July 30, 2024
• Study Completion: August 25, 2024
• Last Updated: September 3, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: one or two months

Locations

TU (1)