Trials Sponsors Conditions Drugs Pricing

Conditions

Keywords

Magnetic resonance spectroscopic imagingClinical DeteriorationNeurotransmitterNeurometaboliteMetabolic network connectivity

Outcome Measures

Primary Outcomes (1)

Early neurological deterioration
It is defined as an increase of ≥4 points from baseline NIHSS at hospital arrival, and excluding non-ischemic causes such as hemorrhagic transformation and epilepsy.
24 hours

Secondary Outcomes (4)

Neurological functional outcome
90 days
Composite Temporal and spatial dynamic changes of the neurometabolites
acute stage (within 24 hours), the subacute stage (5-7 days) and the chronic stage (90 days)
Composite Temporal and spatial dynamic changes of the neurotransmitters
acute stage (within 24 hours), the subacute stage (5-7 days) and the chronic stage (90 days)
Changes in whole-brain metabolic network connectivity
acute stage (within 24 hours), the subacute stage (5-7 days) and the chronic stage (90 days)

Study Arms (1)

LVO-MIS

Acute minor ischemic stroke induced by large vessel occlusion (LVO-MIS) within 24 hours

Diagnostic Test: Magnetic resonance spectroscopic imaging

Interventions

Magnetic resonance spectroscopic imagingDiagnostic test

High-resolution 3D metabolic imaging was performed using the SPICE 1H-MRSI sequence.

LVO-MIS

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 100 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Patients who are older than 18 years of age diagnosed with acute mild ischemic stroke with large vessel occlusion (LVO-MIS) within 24 hours of onset will be enrolled into the study.

You may qualify if:

Adult (age ≥ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery;

Sponsors & Collaborators

Shanghai 6th People's Hospital
Otherlead

Study Sites (1)

Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 213000, China

RECRUITING

Jiangshan Deng, MDCONTACTjohnson120@126.com

MeSH Terms

Conditions

Ischemic StrokeClinical Deterioration

Interventions

Positron-Emission Tomography

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular DiseasesDisease ProgressionDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

Li Cao, phD
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
PRINCIPAL INVESTIGATOR

Central Study Contacts

Li Cao, phD

CONTACT

+86 21 64369263 caoli2000@yeah.net

Jiangshan Deng, phD

CONTACT

+86 21 64369181

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: PROSPECTIVE
Target Duration: 3 Months
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Professor

Study Record Dates

First Submitted

June 10, 2024

First Posted

June 13, 2024

Study Start

August 15, 2024

Actual (reported)

Primary Completion

September 30, 2027

Estimated

MRSI Evaluation for Minor Stroke With Large Vessel Occlusion

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (1)

LVO-MIS

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (4)

Study Arms (1)

LVO-MIS

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations