Barriers and Facilitators to MMR Vaccination Among Healthcare Workers

NCT06456788 | Completed

• 1 other identifier: 344919
• Study Type: observational
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

Measles is a highly contagious disease which can result in severe complications in some patients. Healthcare workers have a higher risk of getting measles than the general population because of their increased risk of exposure from patients with measles attending hospitals. Having had measles in the past or at least one dose of the measles, mumps and rubella (MMR) vaccine provides protection (immunity) against measles. UK government guidelines therefore recommend that healthcare workers and non-clinical staff with direct patient contact are fully vaccinated or have other evidence of immunity. Yet, evidence from recent measles outbreaks suggests that some healthcare workers are not immune or do not know if they are immune, with implications for containment efforts, cost and transmission. The purpose of this study is to identify barriers and facilitators to uptake of the MMR vaccine among healthcare workers at King's College Hospital NHS Foundation Trust (KCH). KCH healthcare workers will be eligible to take part in the study if they are aged 18 and over and have direct contact with patients. In addition, the research will focus on four subgroups of healthcare workers at KCH: those who are not immune, those who have not completed the full vaccination schedule, those who don't know their immunity status, those received the vaccine only after joining KCH. The latter may provide insights into facilitators to vaccine uptake. Measles immunity forms part of the occupational health screening at KCH. A series of semi structured interviews lasting approximately 1 hour will explore participants' experiences of the occupational health vaccine screening process and measles vaccine campaigns at KCH; why they are unvaccinated/not fully vaccinated/do not know if they are immune/decided to be vaccinated after joining KCH; and what measures or interventions may help healthcare workers when deciding whether to get the MMR vaccine.

Conditions

Measles

Outcome Measures

Primary Outcomes (3)

• Barriers to MMR vaccination

  Barriers to MMR vaccination will be explored in the qualitative interview

  Collected at one timepoint 1 day during qualitative interview

• Facilitators to MMR vaccination

  Facilitators to MMR vaccination will be explored in the qualitative interview

  Collected at one timepoint 1 day during qualitative interview

• Reasons for not knowing immunity status

  Reasons for not knowing immunity status will be explored in the qualitative interview

  Collected at one timepoint 1 day during qualitative interview

Secondary Outcomes (1)

• Experiences of the occupational health vaccine screening process at KCH

  Collected at one timepoint 1 day during qualitative interview

Study Arms (1)

Healthcare workers

Healthcare workers at one Trust who have direct patient contact and fall within one of four groups: 1) they are not immune to measles (have not had measles in the past and have not been vaccinated with both doses of the MMR vaccine), 2) they have not completed the full vaccination schedule (they have received only 1 dose of the MMR vaccine), 3) they do not know their immunity status, and 4) they received the MMR vaccine after joining the Trust.

Biological: MMR vaccination

Interventions

MMR vaccination BIOLOGICAL

MMR vaccination status

Healthcare workers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from a population of hospital-based healthcare workers, including doctors, nurses, health assistants, etc. Healthcare workers will be recruited from one site only (KCH).

You may qualify if:

• Are aged 18 and over
• Currently work as a healthcare worker at the Trust
• Have direct contact with patients
• Don't know if they have had measles and don't know if they have been vaccinated
• Or: Have not had measles and have not received the MMR vaccine
• Or: Have only received 1 dose of the MMR vaccine
• Or: Received the MMR vaccine after joining the Trust

You may not qualify if:

• Are aged \<18 years old
• Work in a role at the Trust that does not involve direct contact with patients (e.g., administrative or business staff)
• Are sure and/or have evidence that they have had measles in the past or both doses of the MMR vaccine before joining the Trust
• Are not able to give informed consent

Sponsors & Collaborators

• King's College London: lead
• King's College Hospital NHS Trust: collaborator
• UK Health Security Agency: collaborator

Study Sites (1)

King's College London

London, London, United Kingdom

Location

MeSH Terms

Conditions

Measles

Condition Hierarchy (Ancestors)

Morbillivirus Infections; Paramyxoviridae Infections; Mononegavirales Infections; RNA Virus Infections; Virus Diseases; Infections

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2024
• First Posted: June 13, 2024
• Study Start: September 12, 2024
• Primary Completion: December 19, 2024
• Study Completion: December 19, 2024
• Last Updated: May 6, 2025

Record last verified: 2025-04

Locations

GB (1)